(3-Chloropyridin-2-yl)methanol

Base Information

• Chemical Name: (3-Chloropyridin-2-yl)methanol
• CAS No.: 60588-81-0
• Molecular Formula: C6H6ClNO
• Molecular Weight: 143.573
• Hs Code.: 2933399090
• European Community (EC) Number: 865-008-6
• DSSTox Substance ID: DTXSID60440625
• Wikidata: Q72458545
• Mol file: 60588-81-0.mol

Synonyms:(3-chloropyridin-2-yl)methanol;60588-81-0;3-CHLOROPYRIDINE-2-METHANOL;MFCD11110226;3-chloro-2-pyridinemethanol;(3-CHLORO-2-PYRIDYL)METHANOL;3-CHLORO-2-(HYDROXYMETHYL)PYRIDINE;SCHEMBL2082784;3-chloro-2-hydroxymethylpyridine;AMY8066;DTXSID60440625;3-chloro-2-hydroxymethyl-pyridine;VCJIRTWLMWNXEA-UHFFFAOYSA-N;(3-Chloro-pyridin-2-yl)-methanol;BBL101604;STL555400;AKOS005765944;AB63515;CS-W019890;GE-0733;SY102632;FT-0681986;EN300-305135;A868935;J-501204

Chemical Property of (3-Chloropyridin-2-yl)methanol

Chemical Property:

• Vapor Pressure: 0.028mmHg at 25°C
• Boiling Point: 234.897oC at 760 mmHg
• PKA: 12.80±0.10(Predicted)
• Flash Point: 95.862oC
• PSA: 33.12000
• Density: 1.324g/cm3
• LogP: 1.22730
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 143.0137915
• Heavy Atom Count: 9
• Complexity: 89.1

Purity/Quality:

97% ^*data from raw suppliers

(3-Chloropyridin-2-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(N=C1)CO)Cl

Technology Process of (3-Chloropyridin-2-yl)methanol

There total 10 articles about (3-Chloropyridin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

3-chloropyridine-2-carboxylic acid (57266-69-0) → 3-chloro-2-hydroxy-methyl-pyridine (60588-81-0)

Guidance literature:

3-chloropyridine-2-carboxylic acid; With isopropyl chloroformate; triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

With sodium tetrahydroborate; at 20 ℃; for 2h;

Reference yield: 47.0%

2-bromo-3-chloropyridine (96424-68-9) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-chloro-2-hydroxy-methyl-pyridine (60588-81-0)

Guidance literature:

2-bromo-3-chloropyridine; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.0833333h;

N,N-dimethyl-formamide; In diethyl ether; hexane; at -78 - -10 ℃;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 1h;

DOI:10.1002/chem.201902817

Reference yield:

3-amino-2-hydroxy-methylpyridine (52378-63-9) → 3-chloro-2-hydroxy-methyl-pyridine (60588-81-0)

Guidance literature:

With sodium nitrite; copper(I) chloride; In hydrogenchloride; water;

upstream raw materials:

Acetic acid 3-chloro-pyridin-2-ylmethyl ester

3-chloropyridine-2-carboxylic acid

3-chloro-2-methylpyridine

3-Chlor-2-picolin-1-oxid

Downstream raw materials:

3-chloro-2-(chloromethyl)pyridine

3-chloropyridine-2-carboxaldehyde