Methyl 4-aMino-3-fluoro-2-((2-fluorophenyl)aMino)-5-nitrobenzoate

Base Information

Chemical Name:Methyl 4-aMino-3-fluoro-2-((2-fluorophenyl)aMino)-5-nitrobenzoate
CAS No.:606143-94-6
Molecular Formula:C14H11F2N3O4
Molecular Weight:323.256
Hs Code.:
Mol file:606143-94-6.mol

Synonyms:4-amino-3-fluoro-5-methyl pyridine;4-Amino-3-fluor-5-methyl-pyridin;4-amino-3-fluoro-2-(2-fluoro-phenylamino)-5-nitro-benzoic acid methyl ester;4-AMINO-5-FLUORO-3-PICOLINE;3-fluoro-5-methyl-pyridin-4-ylamine;4-AMINO-3-FLUORO-5-PICOLINE;

Suppliers and Price of Methyl 4-aMino-3-fluoro-2-((2-fluorophenyl)aMino)-5-nitrobenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
methyl4-amino-3-fluoro-2-((2-fluorophenyl)amino)-5-nitrobenzoate
500mg
$ 800.00

Total 13 raw suppliers

Chemical Property of Methyl 4-aMino-3-fluoro-2-((2-fluorophenyl)aMino)-5-nitrobenzoate

Chemical Property:

Boiling Point:449.1±45.0 °C(Predicted)
PKA:-4.01±0.25(Predicted)
PSA：110.17000
Density:1.497±0.06 g/cm3(Predicted)
LogP:4.16280

Purity/Quality:

97% ^*data from raw suppliers

methyl4-amino-3-fluoro-2-((2-fluorophenyl)amino)-5-nitrobenzoate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Methyl 4-aMino-3-fluoro-2-((2-fluorophenyl)aMino)-5-nitrobenzoate

There total 4 articles about Methyl 4-aMino-3-fluoro-2-((2-fluorophenyl)aMino)-5-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 284030-58-6
4-Amino-2,3-difluoro-5-nitro-benzoic acid methyl ester

: 348-54-9
2-Fluoroaniline

: 606143-94-6
4-amino-3-fluoro-2-(2-fluoro-phenylamino)-5-nitro-benzoic acid methyl ester

Guidance literature:: In xylene; at 140 ℃; for 144h;

Reference yield:

: 197520-71-1
2,3,4-trifluoro-5-nitro-benzoic acid

: 606143-94-6
4-amino-3-fluoro-2-(2-fluoro-phenylamino)-5-nitro-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium hydroxide / water / 2.5 h / 0 - 20 °C

2: hexane; tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C / Inert atmosphere

3: 5,5-dimethyl-1,3-cyclohexadiene / 144 h / 140 °C / Inert atmosphere

With ammonium hydroxide; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; hexane; water;

Reference yield:

: 61079-72-9
2,3,4,-trifluorobenzoic acid

: 606143-94-6
4-amino-3-fluoro-2-(2-fluoro-phenylamino)-5-nitro-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid; nitric acid / 2.5 h

2: ammonium hydroxide / water / 2.5 h / 0 - 20 °C

3: hexane; tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C / Inert atmosphere

4: 5,5-dimethyl-1,3-cyclohexadiene / 144 h / 140 °C / Inert atmosphere

With sulfuric acid; nitric acid; ammonium hydroxide; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; hexane; water;