284030-58-6

Basic information

• Product Name: METHYL 4-AMINO-2,3-DIFLUORO-5-NITROBENZOATE
• Synonyms: METHYL 4-AMINO-2,3-DIFLUORO-5-NITROBENZOATE;4-AMINO-2,3-DIFLUORO-5-NITRO-BENZOIC ACID METHYL ESTER;4-Nitro-2,3-Difluoro-5-Nitro Benzoic Acid Methyl Ester;Benzoic acid,4-aMino-2,3-difluoro-5-nitro-, Methyl ester;4-amino-2,3-difluoro-5-nitrobenzoate
• CAS NO: 284030-58-6
• Molecular Formula: C₈H₆F₂N₂O₄
• Molecular Weight: 232.14
• Product Categories: Phenylacetic acid
• Mol File: 284030-58-6.mol
• Article Data: 11

Chemical Properties

• Melting Point: 184-186°C
• Boiling Point: 402 °C at 760 mmHg
• Flash Point: 196.9 °C
• Appearance: /
• Density: 1.548 g/cm³
• Vapor Pressure: 1.14E-06mmHg at 25°C
• Refractive Index: 1.564
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: -5.22±0.25(Predicted)
• CAS DataBase Reference: METHYL 4-AMINO-2,3-DIFLUORO-5-NITROBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4-AMINO-2,3-DIFLUORO-5-NITROBENZOATE(284030-58-6)
• EPA Substance Registry System: METHYL 4-AMINO-2,3-DIFLUORO-5-NITROBENZOATE(284030-58-6)

Safety Data

• Hazardous Substances Data: 284030-58-6(Hazardous Substances Data)

Usage

General Description

Methyl 4-amino-2,3-difluoro-5-nitrobenzoate is a chemical compound with the molecular formula C8H6F2N2O4. It is a derivative of benzoic acid and contains a methyl group, an amino group, two fluorine atoms, and a nitro group. METHYL 4-AMINO-2,3-DIFLUORO-5-NITROBENZOATE is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has potential applications in the development of anti-cancer, anti-inflammatory, and antimicrobial drugs. Methyl 4-amino-2,3-difluoro-5-nitrobenzoate should be handled and stored according to standard laboratory procedures to ensure safety and prevent any potential hazards.

InChI:InChI=1/C8H6F2N2O4/c1-16-8(13)3-2-4(12(14)15)7(11)6(10)5(3)9/h2H,11H2,1H3

Upstream product

• 284030-57-5 4-amino-2,3-difluoro-5-nitro-benzoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 186581-53-3 diazomethane 
• 67-56-1 methanol 
• 197520-71-1 2,3,4-trifluoro-5-nitro-benzoic acid 
• 61079-72-9 2,3,4,-trifluorobenzoic acid 

Downstream Products

• 606143-95-7 4-amino-3-fluoro-2-(2-methyl-4-trifluoromethoxy-phenylamino)-5-nitro-benzoic acid methyl ester 
• 606143-94-6 4-amino-3-fluoro-2-(2-fluoro-phenylamino)-5-nitro-benzoic acid methyl ester 
• 284030-59-7 4-Amino-3-fluoro-5-nitro-2-o-tolylamino-benzoic acid methyl ester 
• 918321-18-3 methyl 2,4-diamino-3-fluoro-5-nitrobenzoate 
• 1360624-53-8 2-(2,2,2-trifluoro-ethoxy)-3-fluoro-4-amino-5-nitro-benzoic acid methyl ester 
• 606093-58-7 4-Amino-3-fluoro-5-nitro-2-phenylamino-benzoic acid methyl ester 
• 606143-98-0 4-amino-2-(2-chloro-phenylamino)-3-fluoro-5-nitro-benzoic acid methyl ester 
• 917980-11-1 4-amino-2,3-difluoro-5-nitrobenzamide 

Relevant articles and documents

FORMS OF BINIMETINIB AND PROCESS FOR PREPARATION THEREOF

Amorphous forms of Binimetinib and processes for the preparation thereof.

COMBINATION THERAPY

The present invention relates to a pharmaceutical combination comprising a MEK inhibitor compound 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)- amide or a pharmaceutically acceptable salt thereof and the IGFIR inhibitor ANTIBODY A, a pharmaceutical composition comprising such combination, methods for treating cancer comprising administration of a therapeutically effective amount of such combination to a subject in need thereof, and uses of such combination for the treatment of cancer.

PROCESS FOR PREPARING BENZIMIDAZOLE COMPOUNDS

Provided are methods for the synthesis of heterocyclic compounds such as benzimidazole carboxylic acid core structures having Formula Ia-1 and their synthetic intermediates: wherein Z, X1, X2, X5, R2 and R10 are as defined herein. Compounds of Formula Ia-1 and their synthetic intermediates can be used to prepare heterocyclic derivatives such as benzimidazole derivatives.