2,4-Dimethoxy-5-nitropyridine

Base Information

• Chemical Name: 2,4-Dimethoxy-5-nitropyridine
• CAS No.: 607373-84-2
• Molecular Formula: C7H8N2O4
• Molecular Weight: 184.152
• Hs Code.: 2933399090
• Mol file: 607373-84-2.mol

Synonyms:Pyridine,2,4-dimethoxy-5-nitro;

Chemical Property of 2,4-Dimethoxy-5-nitropyridine

Chemical Property:

• PSA: 77.17000
• Density: 1.292
• LogP: 1.53020
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2,4-Dimethoxy-5-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Dimethoxy-5-nitropyridine

There total 2 articles about 2,4-Dimethoxy-5-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydroxy-4-methoxy-5-nitro pyridine (607373-82-0) + sodium methylate (124-41-4) → 2,4-dimethoxy-5-nitropyridine (607373-84-2)

Guidance literature:

2-hydroxy-4-methoxy-5-nitro pyridine; With trichlorophosphate; In toluene; at 80 ℃;

sodium methylate; In methanol; at 15 - 20 ℃; for 6h;

DOI:10.1021/jm060873p

Reference yield:

4-methoxy-3-nitro-pyridine (31872-62-5) → 2,4-dimethoxy-5-nitropyridine (607373-84-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 91 percent / potassium t-butoxide; t-BuOOH / tetrahydrofuran; decane; liquid ammonia / 2 h / -35 °C

2.1: POCl₃ / toluene / 80 °C

2.2: methanol / 6 h / 15 - 20 °C

With tert.-butylhydroperoxide; potassium tert-butylate; trichlorophosphate; In tetrahydrofuran; decane; ammonia; toluene;

DOI:10.1021/jm060873p

Reference yield: 99.0%

2,4-dimethoxy-5-nitropyridine (607373-84-2) → 4,6-bis(methyloxy)-3-pyridinamine (89943-34-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; for 7h; under 1500.15 Torr;

upstream raw materials:

2-hydroxy-4-methoxy-5-nitro pyridine

sodium methylate

4-methoxy-3-nitro-pyridine

Downstream raw materials:

[1-ethyl-6-(methyloxy)-1H-imidazo[4,5-c]pyridin-2-yl]acetonitrile

4,6-bis(methyloxy)-3-pyridinamine

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