4,6-Dimethoxypyridin-3-amine

Base Information

• Chemical Name: 4,6-Dimethoxypyridin-3-amine
• CAS No.: 89943-34-0
• Molecular Formula: C7H10 N2 O2
• Molecular Weight: 154.169
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID90696052
• Wikidata: Q82625471
• Mol file: 89943-34-0.mol

Synonyms:4,6-dimethoxypyridin-3-amine;89943-34-0;4,6-DIMETHOXY-PYRIDIN-3-YLAMINE;SCHEMBL1707878;DTXSID90696052;WYPPFWXTKDBNSZ-UHFFFAOYSA-N;4,6-bis(methyloxy)-3-pyridinamine;MFCD09027594;AKOS006289318;AB49206;AC-28219;AS-59364;CS-0100549;FT-0692381;EN300-109982;A843383

Chemical Property of 4,6-Dimethoxypyridin-3-amine

Chemical Property:

• Boiling Point: 291.3±35.0°C at 760 mmHg (Cal.)
• Flash Point: 130.0±25.9°C (Cal.)
• PSA: 57.37000
• Density: 1.2±0.1g/cm3 (Cal.)
• LogP: 1.26220
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 154.074227566
• Heavy Atom Count: 11
• Complexity: 121

Purity/Quality:

97% ^*data from raw suppliers

4,6-Dimethoxy-pyridin-3-ylamine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=NC=C1N)OC

Technology Process of 4,6-Dimethoxypyridin-3-amine

There total 2 articles about 4,6-Dimethoxypyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,4-dimethoxy-5-nitropyridine (607373-84-2) → 4,6-bis(methyloxy)-3-pyridinamine (89943-34-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; for 7h; under 1500.15 Torr;

Reference yield:

2,4-dichloro-5-nitropyridine (4487-56-3) → 4,6-bis(methyloxy)-3-pyridinamine (89943-34-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium / 4.16 h / 0 - 40 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 7 h / 1500.15 Torr

With palladium 10% on activated carbon; hydrogen; sodium; In tetrahydrofuran;

Reference yield: 64.6%

4,6-bis(methyloxy)-3-pyridinamine (89943-34-0) + 1-{[(3S,5S)-5-methyl-1-oxaspiro[2.5]oct-5-yl]methyl}-1H-benzimidazole-6-carbonitrile (1416324-68-9) → 1-(((1S,3S)-3-(((4,6-dimethoxypyridin-3-yl)amino)methyl)-3-hydroxy-1-methylcyclohexaneyl)methyl)-1H-benzo[d]imidazole-6-carbonitrile (1419610-69-7)

Guidance literature:

In isopropyl alcohol; Reflux;

upstream raw materials:

2,4-dimethoxy-5-nitropyridine

2,4-dichloro-5-nitropyridine

Downstream raw materials:

N-(2-(5-chloro-2-(4,6-dimethoxypyridin-3-ylamino)pyrimidin-4-ylamino)-5-methoxyphenyl)methanesulfonamide

1-(((1S,3S)-3-(((4,6-dimethoxypyridin-3-yl)amino)methyl)-3-hydroxy-1-methylcyclohexaneyl)methyl)-1H-benzo[d]imidazole-6-carbonitrile