2-Methyl-5-hydroxyquinoline

Base Information

• Chemical Name: 2-Methyl-5-hydroxyquinoline
• CAS No.: 607-72-7
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.188
• Hs Code.: 2933499090
• Mol file: 607-72-7.mol

Synonyms:2-Methyl-5-hydroxyquinoline;2-metil-5-chinolinolo;5-hydroxy-2-methylquinoline;2-Methyl-chinolin-5-ol;2-methylquinolin-5-ol;5-hydroxyquinaldine;

Chemical Property of 2-Methyl-5-hydroxyquinoline

Chemical Property:

• PSA: 33.12000
• LogP: 2.24880

Purity/Quality:

97% ^*data from raw suppliers

2-methylquinolin-5-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methyl-5-hydroxyquinoline

There total 12 articles about 2-Methyl-5-hydroxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

trans-Crotonaldehyde (123-73-9,4170-30-3) + 2,4-dibromo-5-hydroxyaniline (367521-07-1) → 5-hydroxy-2-methylquinoline (607-72-7)

Guidance literature:

trans-Crotonaldehyde; 2,4-dibromo-5-hydroxyaniline; With hydrogenchloride; acetic acid; for 1h; Heating;

With hydrogen bromide; aniline; for 4h; Further stages.; Heating;

DOI:10.1021/ja0164374

Reference yield: 49.0%

crotonaldehyde (123-73-9,4170-30-3) + 2,4-dibromo-5-hydroxyaniline (367521-07-1) → 5-hydroxy-2-methylquinoline (607-72-7)

Guidance literature:

crotonaldehyde; 2,4-dibromo-5-hydroxyaniline; With hydrogenchloride; In water; acetic acid; for 1.5h; Heating / reflux;

With hydrogen bromide; aniline; In water; acetic acid; for 5h; Heating / reflux;

With sodium hydrogencarbonate; In water; acetic acid;

Reference yield: 49.0%

5,6,7,8-Tetrahydro-2-methylquinolin-5-one (27463-92-9) → 5-hydroxy-2-methylquinoline (607-72-7)

Guidance literature:

5,6,7,8-Tetrahydro-2-methylquinolin-5-one; With hydrogen bromide; bromine; In water; at 60 ℃; for 1h;

With lithium carbonate; lithium bromide; In N,N-dimethyl-formamide; at 150 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jm8001444

upstream raw materials:

2-methyl-5-aminoquinoline

trans-Crotonaldehyde

2,4-dibromo-5-hydroxyaniline

2-methyl-5-nitroquinoline

Downstream raw materials:

2-methyl-1,2,3,4-tetrahydro-5-quinolinol

2-methyl-5-(2-piperazin-1-ylethoxy)quinoline

5-hydroxyquinoline-2-carboxylic acid