2-Methyl-1,2,3,4-tetrahydroquinolin-5-ol

Base Information

• Chemical Name: 2-Methyl-1,2,3,4-tetrahydroquinolin-5-ol
• CAS No.: 108825-11-2
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.219
• European Community (EC) Number: 823-176-8
• DSSTox Substance ID: DTXSID20910879
• Nikkaji Number: J861.561F
• Mol file: 108825-11-2.mol

Synonyms:2-methyl-1,2,3,4-tetrahydroquinolin-5-ol;108825-11-2;1,2,3,4-Tetrahydro-2-methyl-5-quinolinol;5-Quinolinol, 1,2,3,4-tetrahydro-2-methyl-;2-Metil-1,2,3,4-tetraidro-5-chinolinolo [Italian];2-Metil-1,2,3,4-tetraidro-5-chinolinolo;DTXSID20910879;LS-142588;EN300-1716950;Z1262576864

Chemical Property of 2-Methyl-1,2,3,4-tetrahydroquinolin-5-ol

Chemical Property:

• Vapor Pressure: 0.000571mmHg at 25°C
• Boiling Point: 301.9°Cat760mmHg
• Flash Point: 142°C
• PSA: 32.26000
• Density: 1.082g/cm³
• LogP: 2.27680
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 163.099714038
• Heavy Atom Count: 12
• Complexity: 160

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CCC2=C(N1)C=CC=C2O

Technology Process of 2-Methyl-1,2,3,4-tetrahydroquinolin-5-ol

There total 3 articles about 2-Methyl-1,2,3,4-tetrahydroquinolin-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

5-hydroxy-2-methylquinoline (607-72-7) → 2-methyl-1,2,3,4-tetrahydro-5-quinolinol (108825-11-2)

Guidance literature:

With borane pyridine; In acetic acid; for 24h; Ambient temperature;

Reference yield:

2-methyl-5-nitroquinoline (23877-94-3) → 2-methyl-1,2,3,4-tetrahydro-5-quinolinol (108825-11-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / Pd/CaCO₃ / ethanol; H₂SO₄

2: 32 percent / NaNO₂, CuNO₃*3H₂O, CuO / H₂O

3: 57 percent / borane-pyridine complex / acetic acid / 24 h / Ambient temperature

With cuprous nitrate; borane pyridine; copper(II) oxide; sodium nitrite; Lindlar's catalyst; In ethanol; sulfuric acid; water; acetic acid;

Reference yield:

2-methyl-5-aminoquinoline (54408-50-3) → 2-methyl-1,2,3,4-tetrahydro-5-quinolinol (108825-11-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 32 percent / NaNO₂, CuNO₃*3H₂O, CuO / H₂O

2: 57 percent / borane-pyridine complex / acetic acid / 24 h / Ambient temperature

With cuprous nitrate; borane pyridine; copper(II) oxide; sodium nitrite; In water; acetic acid;

upstream raw materials:

5-hydroxy-2-methylquinoline

2-methyl-5-aminoquinoline

2-methyl-5-nitroquinoline