4-(1,1-Dimethylethyl)thiazole

Base Information

• Chemical Name: 4-(1,1-Dimethylethyl)thiazole
• CAS No.: 6081-24-9
• Molecular Formula: C7H11NS
• Molecular Weight: 141.23400
• Hs Code.: 2934100090
• Mol file: 6081-24-9.mol

Synonyms:Thiazole,4-(1,1-dimethylethyl);4-tert-butyl-thiazole;Thiazole,4-tert-butyl;4-t-butylthiazole;4-tert.-Butyl-thiazol;

Chemical Property of 4-(1,1-Dimethylethyl)thiazole

Chemical Property:

• Boiling Point: 78 °C(Press: 12 Torr)
• PKA: 3.19±0.10(Predicted)
• PSA: 41.13000
• Density: 1.017±0.06 g/cm3(Predicted)
• LogP: 2.44060

Purity/Quality:

95% ^*data from raw suppliers

4-(1,1-dimethylethyl)-Thiazole 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(1,1-Dimethylethyl)thiazole

There total 2 articles about 4-(1,1-Dimethylethyl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

thiocarboxamide (115-08-2) + 1-Bromopinacolon (5469-26-1) → 4-tert-Butylthiazol (6081-24-9)

Guidance literature:

In acetone;

Reference yield:

formamide (77287-34-4,77287-35-5,60100-09-6) + 1-Bromopinacolon (5469-26-1) → 4-tert-Butylthiazol (6081-24-9)

Guidance literature:

With tetraphosphorus decasulfide; 1.) ice-salt bath, 2.) 90 deg C, 1 h;

Reference yield:

4-tert-Butylthiazol (6081-24-9) → 2-acetamido-4-t-butylthiazole (82245-97-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) hexane, 65 min, -70 deg C, 2.) 40 min

2: 1.) NH₂OH*HCl, NaOAc, 2.) PCl₅ / 1.) H₂O-EtOH, reflux, 3h, 2.) Et₂O, steam bath

With n-butyllithium; phosphorus pentachloride; hydroxylamine hydrochloride; sodium acetate;

upstream raw materials:

formamide

1-Bromopinacolon

thiocarboxamide

Downstream raw materials:

2-acetamido-4-t-butylthiazole