N-(4-tert-butyl-1,3-thiazol-2-yl)acetamide

Base Information

• Chemical Name: N-(4-tert-butyl-1,3-thiazol-2-yl)acetamide
• CAS No.: 82245-97-4
• Molecular Formula: C₉H₁₄N₂OS
• Molecular Weight: 198.289
• Mol file: 82245-97-4.mol

Synonyms:N-(4-tert-butyl-thiazol-2-yl)-acetamide;N-(4-tert-Butyl-thiazol-2-yl)-acetamid;

Chemical Property of N-(4-tert-butyl-1,3-thiazol-2-yl)acetamide

Chemical Property:

• Melting Point: 180 - 182 °C (H2O)
• PSA: 70.23000
• LogP: 2.47200

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-tert-butyl-1,3-thiazol-2-yl)acetamide

There total 8 articles about N-(4-tert-butyl-1,3-thiazol-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,3-dimethyl-butan-2-one (75-97-8) → 2-acetamido-4-t-butylthiazole (82245-97-4)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine

With iodine;

DOI:10.1021/ja01164a110

Reference yield:

2-amino-4-tert-butylthiazole (74370-93-7) + acetic anhydride (108-24-7) → 2-acetamido-4-t-butylthiazole (82245-97-4)

Guidance literature:

DOI:10.1021/jo01122a013 DOI:10.1021/ja01164a110

Reference yield:

2-amino-4-tert-butylthiazole (74370-93-7) + acetyl chloride (75-36-5) → 2-acetamido-4-t-butylthiazole (82245-97-4)

Guidance literature:

DOI:10.1021/jo01122a013 DOI:10.1021/ja01164a110

upstream raw materials:

2-amino-4-tert-butylthiazole

acetic anhydride

acetyl chloride

1-Bromopinacolon