2-Hydroxy-3-iodo-5-methylbenzoic acid

Base Information

• Chemical Name: 2-Hydroxy-3-iodo-5-methylbenzoic acid
• CAS No.: 6083-00-7
• Molecular Formula: C8H7IO3
• Molecular Weight: 278.046
• DSSTox Substance ID: DTXSID20501807
• Wikidata: Q82354423

Synonyms:2-Hydroxy-3-iodo-5-methylbenzoic acid;6083-00-7;DTXSID20501807;AT22678;EN300-1722167;Z2787468595

Chemical Property of 2-Hydroxy-3-iodo-5-methylbenzoic acid

Chemical Property:

• XLogP3: 4.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 277.94399
• Heavy Atom Count: 12
• Complexity: 183

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C(=C1)I)O)C(=O)O

Technology Process of 2-Hydroxy-3-iodo-5-methylbenzoic acid

There total 2 articles about 2-Hydroxy-3-iodo-5-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-Methylsalicylic acid (89-56-5) → 2-Hydroxy-3-iod-5-methyl-benzoesaeure (6083-00-7)

Guidance literature:

With sodium hypochlorite; sodium iodide; sodium hydroxide; In methanol; water; at 0 ℃; for 2h;

DOI:10.1021/jacs.0c13057

Reference yield:

→ 2-Hydroxy-3-iod-5-methyl-benzoesaeure (6083-00-7)

Guidance literature:

2-Hydroxy-5-methyl-benzoesaeure, I2, H2SO4, EtOH, 60grad;

DOI:10.1039/j39660000321

Reference yield: 66.0%

2-Hydroxy-3-iod-5-methyl-benzoesaeure (6083-00-7) + diphenylphosphane (829-85-6) → 3-diphenylphosphanyl-2-hydroxy-5-methyl-benzoic acid

Guidance literature:

With triethylamine; palladium diacetate; In acetonitrile; at 90 ℃; for 48h;

DOI:10.1016/S0022-328X(01)01371-7

upstream raw materials:

5-Methylsalicylic acid

Downstream raw materials:

Methyl 3-iodo-2-methoxy-5-methylbenzoate

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