Methyl 4-amino-2-morpholinothiazole-5-carboxylate

Base Information

• Chemical Name: Methyl 4-amino-2-morpholinothiazole-5-carboxylate
• CAS No.: 99967-78-9
• Molecular Formula: C₉H₁₃N₃O₃S
• Molecular Weight: 243.287
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID40377309
• Wikidata: Q82166480
• Mol file: 99967-78-9.mol

Synonyms:99967-78-9;Methyl 4-amino-2-morpholinothiazole-5-carboxylate;methyl 4-amino-2-morpholino-1,3-thiazole-5-carboxylate;methyl 4-amino-2-(morpholin-4-yl)-1,3-thiazole-5-carboxylate;methyl 4-amino-2-morpholin-4-yl-1,3-thiazole-5-carboxylate;Methyl 4-amino-2-morpholino-1.3-thiazole-5-carboxylate;Oprea1_560600;SCHEMBL725151;DTXSID40377309;XRMLHYZIBUGVNR-UHFFFAOYSA-N;ZDA96778;MFCD00139418;AKOS005070698;FT-0642413;EN300-42169;6C-041;J-522290;Z425636056;methyl 4-amino-2-(4-morpholinyl)-1,3-thiazole-5-carboxylate

Chemical Property of Methyl 4-amino-2-morpholinothiazole-5-carboxylate

Chemical Property:

• Vapor Pressure: 2.86E-07mmHg at 25°C
• Melting Point: 157-159°C
• Boiling Point: 420.2°Cat760mmHg
• PKA: 3.70±0.50(Predicted)
• Flash Point: 207.9°C
• PSA: 105.92000
• Density: 1.385g/cm³
• LogP: 0.99470
• Storage Temp.: 2-8°C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 3
• Exact Mass: 243.06776246
• Heavy Atom Count: 16
• Complexity: 260

Purity/Quality:

99%, ^*data from raw suppliers

Methyl 4-amino-2-(morpholin-4-yl)-1,3-thiazole-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C1=C(N=C(S1)N2CCOCC2)N

Technology Process of Methyl 4-amino-2-morpholinothiazole-5-carboxylate

There total 1 articles about Methyl 4-amino-2-morpholinothiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

Methyl thioglycolate (2365-48-2) + S-methyl-N''-cyano-N'-(1-cycloethoxyethyl)carbamimidothioate (32885-06-6) → methyl 4-amino-2-(4-morpholinyl)-1,3-thiazole-5-carboxylate (99967-78-9)

Guidance literature:

With triethylamine; In methanol; for 24h; Ambient temperature;

Reference yield:

methyl 4-amino-2-(4-morpholinyl)-1,3-thiazole-5-carboxylate (99967-78-9) → 4-({[2-methyl-3-(trifluoromethyl)phenyl]methyl}amino)-2-(4-morpholinyl)-1,3-thiazole-5-carboxamide (1256290-37-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 150 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

2.2: 0 - 20 °C

3.1: sodium hydroxide / tetrahydrofuran; methanol / 1 h / 60 °C

With sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol;

DOI:10.1021/ml300045b

Reference yield:

methyl 4-amino-2-(4-morpholinyl)-1,3-thiazole-5-carboxylate (99967-78-9) → 4-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-2-(4-morpholinyl)[1,3]thiazolo[4,5-d]pyrimidin-7(4H)-one (1256289-45-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 150 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

2.2: 0 - 20 °C

With lithium hexamethyldisilazane; In tetrahydrofuran;

DOI:10.1021/ml300045b

upstream raw materials:

Methyl thioglycolate

S-methyl-N''-cyano-N'-(1-cycloethoxyethyl)carbamimidothioate

Downstream raw materials:

4-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-2-(4-morpholinyl)[1,3]thiazolo[4,5-d]pyrimidin-7(4H)-one

5-ethyl-4-(2-methyl-3-(trifluoromethyl)benzyl)-2-morpholino[1,3]thiazolo[4,5-d]pyrimidin-7(4H)-one

4-({[2-methyl-3-(trifluoromethyl)phenyl]methyl}amino)-2-(4-morpholinyl)-1,3-thiazole-5-carboxamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 99967-78-9 METHYL 4-AMINO-2-MORPHOLINO-1,3-THIAZOLE-5-CARBOXYLATE

Send

Send

Metric Ton KG G Pound L ML

Send

Send