Technology Process of Pentanamide,
N-[(1R)-1-(1,3-dioxolan-2-yl)-2-phenylethyl]-2-hydroxy-4-methyl-, (2S)-
There total 6 articles about Pentanamide,
N-[(1R)-1-(1,3-dioxolan-2-yl)-2-phenylethyl]-2-hydroxy-4-methyl-, (2S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
3-dimethylaminopropylcarbodiimide monohydrochloride; benzotriazol-1-ol; triethylamine;
In
dichloromethane; N,N-dimethyl-formamide;
at 20 ℃;
for 18h;
DOI:10.1016/j.bmc.2003.09.031
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 89 percent / Et3N / tetrahydrofuran / 18 h / 20 °C
2: 81 percent / ethyldiisopropylamine; SO3/pyridine / CH2Cl2; dimethylsulfoxide / 0.5 h / cooling
3: 71 percent / pyridinium tosylate / toluene / 18 h / 80 °C
4: 75 percent / H2 / Pd/C / ethyl acetate / 18 h / 20 °C / atmospheric pressure
5: 81 percent / benzotriazol-1-ol; Et3N; 1-[3-(dimethylamino)propyl]carbodiimide*HCl / dimethylformamide; CH2Cl2 / 18 h / 20 °C
With
pyridine; 3-dimethylaminopropylcarbodiimide monohydrochloride; sulfur trioxide; hydrogen; pyridinium p-toluenesulfonate; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2003.09.031
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 81 percent / ethyldiisopropylamine; SO3/pyridine / CH2Cl2; dimethylsulfoxide / 0.5 h / cooling
2: 71 percent / pyridinium tosylate / toluene / 18 h / 80 °C
3: 75 percent / H2 / Pd/C / ethyl acetate / 18 h / 20 °C / atmospheric pressure
4: 81 percent / benzotriazol-1-ol; Et3N; 1-[3-(dimethylamino)propyl]carbodiimide*HCl / dimethylformamide; CH2Cl2 / 18 h / 20 °C
With
pyridine; 3-dimethylaminopropylcarbodiimide monohydrochloride; sulfur trioxide; hydrogen; pyridinium p-toluenesulfonate; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2003.09.031