Technology Process of (1R)-1-(1,3-dioxolan-2-yl)-2-phenylethanamine
There total 7 articles about (1R)-1-(1,3-dioxolan-2-yl)-2-phenylethanamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethyl acetate;
at 20 ℃;
for 18h;
atmospheric pressure;
DOI:10.1016/j.bmc.2003.09.031
- Guidance literature:
-
Multi-step reaction with 4 steps
1: i-Pr2NEt; HBTU; HOBt / dimethylformamide / 2 h / 25 °C
2: LiAlH4 / tetrahydrofuran / 0.5 h / 0 - 25 °C
3: TsOH / toluene / 6 h / Heating
4: 1,4-cyclohexadiene / Pd(OH)2 / ethyl acetate / 4 h
With
lithium aluminium tetrahydride; cyclohexa-1,4-diene; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine;
palladium dihydroxide;
In
tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; toluene;
1: Acylation / 2: Reduction / 3: Condensation / 4: carbamate cleavage;
DOI:10.1016/S0040-4039(00)00950-3
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 71 percent / pyridinium tosylate / toluene / 18 h / 80 °C
2: 75 percent / H2 / Pd/C / ethyl acetate / 18 h / 20 °C / atmospheric pressure
With
hydrogen; pyridinium p-toluenesulfonate;
palladium on activated charcoal;
In
ethyl acetate; toluene;
DOI:10.1016/j.bmc.2003.09.031
