Pyridine, 3-bromo-4-chloro-5-(2-phenyl-1-naphthalenyl)-

Base Information

Chemical Name:Pyridine, 3-bromo-4-chloro-5-(2-phenyl-1-naphthalenyl)-
CAS No.:612086-26-7
Molecular Formula:C21H13BrClN
Molecular Weight:394.698
Hs Code.:
DSSTox Substance ID:DTXSID50449425
Wikidata:Q82268885

Synonyms:612086-26-7;Pyridine, 3-bromo-4-chloro-5-(2-phenyl-1-naphthalenyl)-;SCHEMBL6233147;DTXSID50449425

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Chemical Property of Pyridine, 3-bromo-4-chloro-5-(2-phenyl-1-naphthalenyl)-

Chemical Property:

XLogP3:6.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:392.99199
Heavy Atom Count:24
Complexity:411

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=C(C3=CC=CC=C3C=C2)C4=CN=CC(=C4Cl)Br

Technology Process of Pyridine, 3-bromo-4-chloro-5-(2-phenyl-1-naphthalenyl)-

There total 4 articles about Pyridine, 3-bromo-4-chloro-5-(2-phenyl-1-naphthalenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 13626-17-0
3,5-dibromo-4-chloro-pyridine

: 612086-25-6
4,4,5,5-tetramethyl-2-(2-phenyl-naphthalen-1-yl)-[1,3,2]dioxaborolane

: 612086-26-7
(+/-)-3-bromo-4-chloro-5-(2-phenylnaphthalen-1-yl)pyridine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; silver carbonate; In benzene; for 96h; Heating;

Reference yield:

: 573-97-7
1-bromo-2-naphthol

: 612086-26-7
(+/-)-3-bromo-4-chloro-5-(2-phenylnaphthalen-1-yl)pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 4 h / 0 - 20 °C

2.1: Pd₂(dba)3; 1,3-bis(diphenylphosphino)propane; LiBr / diethyl ether / 7 h / 20 °C

3.1: n-BuLi / diethyl ether; hexane / 0.25 h / -78 °C

3.2: 4.04 g / diethyl ether; hexane / 3 h / -78 - 20 °C

4.1: 80 percent / silver(I) carbonate; Pd(PPh₃)4 / benzene / 96 h / Heating

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; 1,3-bis-(diphenylphosphino)propane; silver carbonate; lithium bromide; In diethyl ether; hexane; benzene; 4.1: Suzuki reaction;

Reference yield:

: 126613-08-9
trifluoromethanesulfonic acid 1-bromonaphthalen-2-yl ester

: 612086-26-7
(+/-)-3-bromo-4-chloro-5-(2-phenylnaphthalen-1-yl)pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: Pd₂(dba)3; 1,3-bis(diphenylphosphino)propane; LiBr / diethyl ether / 7 h / 20 °C

2.1: n-BuLi / diethyl ether; hexane / 0.25 h / -78 °C

2.2: 4.04 g / diethyl ether; hexane / 3 h / -78 - 20 °C

3.1: 80 percent / silver(I) carbonate; Pd(PPh₃)4 / benzene / 96 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; 1,3-bis-(diphenylphosphino)propane; silver carbonate; lithium bromide; In diethyl ether; hexane; benzene; 3.1: Suzuki reaction;