Naphthalene, 1-bromo-2-phenyl-

Base Information

• Chemical Name: Naphthalene, 1-bromo-2-phenyl-
• CAS No.: 22082-93-5
• Molecular Formula: C16H11Br
• Molecular Weight: 283.167
• Mol file: 22082-93-5.mol

Synonyms:1-bromo-2-phenyl-naphthalene;1-Brom-2-phenyl-naphthalin;

Chemical Property of Naphthalene, 1-bromo-2-phenyl-

Chemical Property:

• Melting Point: 63.0 to 67.0 °C
• Boiling Point: 170°C/0.2mmHg(lit.)
• PSA: 0.00000
• LogP: 5.26930

Purity/Quality:

97% ^*data from raw suppliers

1-Bromo-2-phenylnaphthalene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Naphthalene, 1-bromo-2-phenyl-

There total 16 articles about Naphthalene, 1-bromo-2-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

trifluoromethanesulfonic acid 1-bromonaphthalen-2-yl ester (126613-08-9) + phenylmagnesium bromide (100-58-3) → 1-bromo-2-phenylnaphthalene (22082-93-5)

Guidance literature:

trifluoromethanesulfonic acid 1-bromonaphthalen-2-yl ester; With 1,3-bis-(diphenylphosphino)propane; lithium bromide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In diethyl ether; at 20 ℃; for 0.0833333h;

phenylmagnesium bromide; In diethyl ether; at 0 - 20 ℃; for 7h;

Reference yield: 96.0%

o-(phenylethynyl)benzaldehyde (59046-72-9) + phenylacetylene (536-74-3) → 1-bromo-2-phenylnaphthalene (22082-93-5)

Guidance literature:

With N-Bromosuccinimide; copper(II) bis(trifluoromethanesulfonate); In 1,2-dichloro-ethane; at 80 ℃; for 8h; Reagent/catalyst; Solvent; Temperature; Time; regioselective reaction; Catalytic behavior; Inert atmosphere;

DOI:10.1016/j.tet.2020.131872

Reference yield: 89.0%

1-bromo-2-naphthol (573-97-7) + phenylboronic acid (98-80-6) → 1-bromo-2-phenylnaphthalene (22082-93-5)

Guidance literature:

1-bromo-2-naphthol; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h;

With 2,2-dichloro-1,3-dicyclohexylimidazolidine-4,5-dione; In tetrahydrofuran; at 20 ℃; for 1h;

phenylboronic acid; With potassium carbonate; In tetrahydrofuran; at 65 ℃; for 24h;

DOI:10.1002/aoc.5383

upstream raw materials:

2-phenylnaphthalene

trifluoromethanesulfonic acid 1-bromonaphthalen-2-yl ester

phenylmagnesium bromide

1-bromo-2-naphthol

Downstream raw materials:

4,4,5,5-tetramethyl-2-(2-phenyl-naphthalen-1-yl)-[1,3,2]dioxaborolane

bis(2-phenylnaphthalen-1-yl)amine

C₄₂H₂₇Cl

2-(phenyl)-1-(2-methoxyphenyl)naphthalene