L-Tyrosine, 3-hydroxy-O-methyl-, methyl ester, hydrochloride

Base Information

• Chemical Name: L-Tyrosine, 3-hydroxy-O-methyl-, methyl ester, hydrochloride
• CAS No.: 61237-24-9
• Molecular Formula: C11H15NO4.ClH
• Molecular Weight: 261.70200
• Mol file: 61237-24-9.mol

Synonyms:hydrochloride;(S)-2-Amino-3-(3-hydroxy-4-methoxy-phenyl)-propionic acid methyl ester;L-Tyrosine, 3-hydroxy-O-methyl-, methyl ester, hydrochloride;

Chemical Property of L-Tyrosine, 3-hydroxy-O-methyl-, methyl ester, hydrochloride

Chemical Property:

• PSA: 81.78000
• LogP: 1.94590

Purity/Quality:

99% ^*data from raw suppliers

Methyl (2S)-2-amino-3-(3-hydroxy-4-methoxyphenyl)propanoate HCl 95+% ee ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Tyrosine, 3-hydroxy-O-methyl-, methyl ester, hydrochloride

There total 1 articles about L-Tyrosine, 3-hydroxy-O-methyl-, methyl ester, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + (S)-2-Formylamino-3-(3-hydroxy-4-methoxy-phenyl)-propionic acid → L-m-hydroxy-p-methoxyphenylalanine methyl ester hydrochloride (61237-24-9)

Guidance literature:

With hydrogenchloride; Yield given. Multistep reaction; 1.) 100 deg C, 4 h;

DOI:10.1021/jm00178a013

Reference yield:

L-m-hydroxy-p-methoxyphenylalanine methyl ester hydrochloride (61237-24-9) → L-aspartyl-L-m-hydroxy-p-methoxyphenylalanine methyl ester (72683-74-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N, DCC / CH₂Cl₂ / 12 h / Ambient temperature

2: H₂ / 10percent Pd/C / acetic acid / 1 h / 2585.7 Torr / Ambient temperature

With hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In dichloromethane; acetic acid;

DOI:10.1021/jm00178a013

Reference yield:

Z-Asp(OBzl)-OH (3479-47-8) + L-m-hydroxy-p-methoxyphenylalanine methyl ester hydrochloride (61237-24-9) → (S)-3-Benzyloxycarbonylamino-N-[(S)-2-(3-hydroxy-4-methoxy-phenyl)-1-methoxycarbonyl-ethyl]-succinamic acid benzyl ester

Guidance literature:

With triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; for 12h; Ambient temperature;

DOI:10.1021/jm00178a013

upstream raw materials:

methanol

Downstream raw materials:

L-aspartyl-L-m-hydroxy-p-methoxyphenylalanine methyl ester

Refernces