N-Formylmethionyl-leucyl-phenylalanyl tert-butyl ester

Base Information

• Chemical Name: N-Formylmethionyl-leucyl-phenylalanyl tert-butyl ester
• CAS No.: 99880-61-2
• Molecular Formula: C₂₅H₃₉N₃O₅S
• Molecular Weight: 493.668
• DSSTox Substance ID: DTXSID50912427
• Mol file: 99880-61-2.mol

Synonyms:FMLP-OtBu;N-formylmethionyl-leucyl-phenylalanyl tert-butyl ester

Chemical Property of N-Formylmethionyl-leucyl-phenylalanyl tert-butyl ester

Chemical Property:

• Vapor Pressure: 6.88E-22mmHg at 25°C
• Boiling Point: 742°Cat760mmHg
• Flash Point: 402.6°C
• PSA: 138.90000
• Density: 1.122g/cm³
• LogP: 4.26280
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 15
• Exact Mass: 493.26104253
• Heavy Atom Count: 34
• Complexity: 661

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCC(C)C(C(=O)NC(CC1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)C(CCSC)NC=O
• Isomeric SMILES: CCC(C)C(C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)[C@H](CCSC)NC=O

Technology Process of N-Formylmethionyl-leucyl-phenylalanyl tert-butyl ester

There total 1 articles about N-Formylmethionyl-leucyl-phenylalanyl tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

For-Met-Leu-OMe (1261486-29-6) + L-phenylalanine tert-butyl ester (16874-17-2) → CHO-Met-Leu-Phe-O-t-Bu (99880-61-2)

Guidance literature:

With cross-linked enzyme aggregates of Alcalase; at 50 ℃; for 20h; Molecular sieve; Enzymatic reaction;

DOI:10.1002/adsc.201000313

Reference yield: 93.0%

methanol (67-56-1) + CHO-Met-Leu-Phe-O-t-Bu (99880-61-2) → N-formylmethionylleucylphenylalanine methyl ester (77543-00-1,65929-03-5)

Guidance literature:

With cross-linked enzyme aggregates of Alcalase; at 50 ℃; for 48h; Molecular sieve; Enzymatic reaction;

DOI:10.1002/adsc.201000313

upstream raw materials:

For-Met-Leu-OMe

L-phenylalanine tert-butyl ester

Downstream raw materials:

N-formylmethionylleucylphenylalanine methyl ester

Refernces