2-(4-BROMO-PHENYL)-1H-INDOLE

Base Information

• Chemical Name: 2-(4-BROMO-PHENYL)-1H-INDOLE
• CAS No.: 6127-49-7
• Molecular Formula: C14H10BrN
• Molecular Weight: 272.144
• Hs Code.: 2933990090
• Mol file: 6127-49-7.mol

Synonyms:

Chemical Property of 2-(4-BROMO-PHENYL)-1H-INDOLE

Chemical Property:

• Vapor Pressure: 1.94E-07mmHg at 25°C
• Boiling Point: 437.3oC at 760 mmHg
• Flash Point: 218.2oC
• PSA: 15.79000
• Density: 1.484g/cm3
• LogP: 4.59740
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

2-(4-Bromophenyl)-1H-indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-BROMO-PHENYL)-1H-INDOLE

There total 54 articles about 2-(4-BROMO-PHENYL)-1H-INDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-((4-bromophenyl)ethynyl)aniline (157869-13-1) → 2-(4-bromophenyl)indole (6127-49-7)

Guidance literature:

With Pt(II)-NaY zeolites; In toluene; at 110 ℃; for 24h;

DOI:10.1021/jacs.5b07304

Reference yield: 95.0%

(2-aminobenzyl)triphenylphosphonium bromide (78133-84-3) + 4-bromo-benzaldehyde (1122-91-4) → 2-(4-bromophenyl)indole (6127-49-7)

Guidance literature:

(2-aminobenzyl)triphenylphosphonium bromide; 4-bromo-benzaldehyde; With acetic acid; In methanol; at 80 ℃; for 0.166667h; Inert atmosphere; Microwave irradiation;

With potassium tert-butylate; In tetrahydrofuran; at 25 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ol801034x

Reference yield: 94.1%

(1E)-1-[1-(4-bromophenyl)ethylidene]-2-phenylhydrazine → 2-(4-bromophenyl)indole (6127-49-7)

Guidance literature:

With PPA; In hexane;

upstream raw materials:

aniline

para-bromophenacyl bromide

4-bromoacetophenone phenylhydrazone

2-[(phenylsulfonyl)methyl]aniline

Downstream raw materials:

2?(4?bromophenyl)?1H?indole?3?carbaldehyde

ethyl [2-(4-bromophenyl)indol-3-yl]dithiocarboxylate

2-(4-bromo-phenyl)-1-ethyl-1H-indole

2-(4-bromo-phenyl)-1H-indole-3-carbodithioic acid methyl ester

Refernces

• 1、 Yuan, Wenkai,Huang, Jie,Xu, Xin,Wang, Long,Tang, Xiang-Ying. "B(C6F5)3-Catalyzed Electron Donor-Acceptor Complex-Mediated Aerobic Sulfenylation of Indoles under Visible-Light Conditions". supporting information. p. 7139 - 7143. Retrieved 2021/09/14.
• 2、 Chen, Wei-Li,Li, Kun,Liang, Cui,Liang, Wang-Fu,Liao, Wei-Cong,Mo, Dong-Liang,Qiu, Pei-Wen,Su, Gui-Fa. "An iron(iii)-catalyzed dehydrogenative cross-coupling reaction of indoles with benzylamines to prepare 3-aminoindole derivatives". supporting information. p. 9610 - 9616. Retrieved 2021/12/09.