2-(4-BROMOPHENYL)-1H-INDOLE-3-CARBALDEHYDE

Base Information

• Chemical Name: 2-(4-BROMOPHENYL)-1H-INDOLE-3-CARBALDEHYDE
• CAS No.: 54031-95-7
• Molecular Formula: C15H10BrNO
• Molecular Weight: 300.154
• Mol file: 54031-95-7.mol

Synonyms:2-(4-Brom-phenyl)-3-formyl-indol;2-(p-bromophenyl)-3-formylindole;2-(4-bromo-phenyl)-indole-3-carbaldehyde;2-(4-Bromo-phenyl)-1H-indole-3-carbaldehyde;

Chemical Property of 2-(4-BROMOPHENYL)-1H-INDOLE-3-CARBALDEHYDE

Chemical Property:

• Melting Point: 258 - 259 °C (ethanol)
• PSA: 32.86000
• LogP: 4.40990

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Bromophenyl)-1h-indole-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

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Technology Process of 2-(4-BROMOPHENYL)-1H-INDOLE-3-CARBALDEHYDE

There total 7 articles about 2-(4-BROMOPHENYL)-1H-INDOLE-3-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 2-(4-bromophenyl)indole (6127-49-7) → 2?(4?bromophenyl)?1H?indole?3?carbaldehyde (54031-95-7)

Guidance literature:

N,N-dimethyl-formamide; With trichlorophosphate; for 1h; Inert atmosphere; Cooling with ice;

2-(4-bromophenyl)indole; at 70 ℃; Inert atmosphere; Cooling with ice;

DOI:10.1007/s11164-019-03765-9

Reference yield:

para-bromoacetophenone (99-90-1) → 2?(4?bromophenyl)?1H?indole?3?carbaldehyde (54031-95-7)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid; ethanol

2: polyphosphoric acid

3: trichlorophosphate

With trichlorophosphate; In ethanol; acetic acid; 3: |Vilsmeier-Haack Formylation;

DOI:10.1007/s00044-011-9861-4

Reference yield:

phenylhydrazine (100-63-0) → 2?(4?bromophenyl)?1H?indole?3?carbaldehyde (54031-95-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / ethanol / 80 °C

1.2: polyphosphoric acid / 120 °C

2.1: trichlorophosphate / 1 h / Inert atmosphere; Cooling with ice

2.2: 70 °C / Inert atmosphere; Cooling with ice

With acetic acid; trichlorophosphate; In ethanol; 1.1: |Fischer Indole Synthesis / 1.2: |Fischer Indole Synthesis / 2.1: |Vilsmeier Reaction / 2.2: |Vilsmeier Reaction;

DOI:10.1007/s11164-019-03765-9

upstream raw materials:

N,N-dimethyl-formamide

2-(4-bromophenyl)indole

para-bromoacetophenone

phenylhydrazine

Downstream raw materials:

(E)-3-[2-(4-Bromo-phenyl)-1H-indol-3-yl]-1-(4-chloro-phenyl)-propenone

(E)-3-[2-(4-Bromo-phenyl)-1H-indol-3-yl]-1-(4-nitro-phenyl)-propenone

2-(4-Bromo-phenyl)-3-[5-(4-chloro-phenyl)-2-(2,4-dinitro-phenyl)-3,4-dihydro-2H-pyrazol-3-yl]-1H-indole

2-amino-4-(2-(4-bromophenyl)-1H-indol-3-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile

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