5-(Chloromethyl)-4-methyl-2-phenyl-1,3-thiazole

Base Information

Chemical Name:5-(Chloromethyl)-4-methyl-2-phenyl-1,3-thiazole
CAS No.:61291-96-1
Molecular Formula:C11H10ClNS
Molecular Weight:223.726
Hs Code.:
DSSTox Substance ID:DTXSID80486888
Wikidata:Q82328468

Synonyms:5-(chloromethyl)-4-methyl-2-phenyl-1,3-thiazole;61291-96-1;SCHEMBL2413521;DTXSID80486888;SKHCQYBEAZCSCN-UHFFFAOYSA-N;AKOS000321139;5-(chloromethyl)-4-methyl-2-phenyl-thiazole;EN300-64484;5-chloromethyl-4-methyl-2-phenyl-1,3-thiazole

Suppliers and Price of 5-(Chloromethyl)-4-methyl-2-phenyl-1,3-thiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 5-(Chloromethyl)-4-methyl-2-phenyl-1,3-thiazole

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:223.0222482
Heavy Atom Count:14
Complexity:182

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(SC(=N1)C2=CC=CC=C2)CCl

Technology Process of 5-(Chloromethyl)-4-methyl-2-phenyl-1,3-thiazole

There total 5 articles about 5-(Chloromethyl)-4-methyl-2-phenyl-1,3-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 61291-91-6
(4-methyl-2-phenyl-1,3-thiazol-5-yl) methanol

: 61291-96-1
5-(chloromethyl)-4-methyl-2-phenylthiazole

Guidance literature:: With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; at 40 ℃; for 4h;
DOI:10.1016/j.ejmech.2016.02.040

Reference yield: 83.0%

: 53715-64-3
4-methyl-2-phenyl-thiazole-5-carboxylic acid ethyl ester

: 61291-96-1
5-(chloromethyl)-4-methyl-2-phenylthiazole

Guidance literature:: 4-methyl-2-phenyl-thiazole-5-carboxylic acid ethyl ester; With sodium tetrahydroborate; In tetrahydrofuran; methanol; Reflux;

With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide; at 40 ℃; for 4h;
DOI:10.1016/j.ejmech.2018.12.069

Reference yield:

: 2227-79-4
benzenecarbothioamide

: 61291-96-1
5-(chloromethyl)-4-methyl-2-phenylthiazole

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 26 h / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

3: methanesulfonyl chloride; triethylamine / dichloromethane / 24 h / 4 °C

With lithium aluminium tetrahydride; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane;