N-(4-methoxyphenyl)-2-chlorobenzylamine

Base Information

• Chemical Name: N-(4-methoxyphenyl)-2-chlorobenzylamine
• CAS No.: 61298-18-8
• Molecular Formula: C14H14ClNO
• Molecular Weight: 247.724
• DSSTox Substance ID: DTXSID40454366
• Nikkaji Number: J1.196.492C
• Wikidata: Q82275855

Synonyms:N-(4-methoxyphenyl)-2-chlorobenzylamine;61298-18-8;Oprea1_845325;Benzenemethanamine, 2-chloro-N-(4-methoxyphenyl)-;SCHEMBL10925241;DTXSID40454366;QJVRBSWBNACXCV-UHFFFAOYSA-N;N-(2-Chlorobenzyl)-4-methoxyaniline;AKOS000241552;FT-0704345

Chemical Property of N-(4-methoxyphenyl)-2-chlorobenzylamine

Chemical Property:

• XLogP3: 4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 247.0763918
• Heavy Atom Count: 17
• Complexity: 216

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)NCC2=CC=CC=C2Cl

Technology Process of N-(4-methoxyphenyl)-2-chlorobenzylamine

There total 7 articles about N-(4-methoxyphenyl)-2-chlorobenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-chloro-benzaldehyde (89-98-5) + 4-methoxy-aniline (104-94-9) → 2-chloro-1-(4-methoxyanilinomethyl)benzene (61298-18-8)

Guidance literature:

With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; In neat (no solvent); at 150 ℃; for 0.25h;

DOI:10.1016/j.tet.2013.04.046

Reference yield: 94.0%

N-(4-methoxyphenyl)-2-chlorobenzylidenimine (17099-11-5,83306-64-3,83306-69-8) → 2-chloro-1-(4-methoxyanilinomethyl)benzene (61298-18-8)

Guidance literature:

With 2-(4'-carboxyphenyl)benzothiazoline; trifluoroacetic acid; In acetonitrile; at 20 ℃; for 23h; Inert atmosphere;

DOI:10.1016/j.tetlet.2011.11.061

Reference yield: 70.0%

(E)-1-(2-chlorophenyl)-N-(4-methoxyphenyl)methanimine (83306-64-3) → 2-chloro-1-(4-methoxyanilinomethyl)benzene (61298-18-8)

Guidance literature:

With polymethylhydrosiloxane; zinc(II) chloride; at 20 ℃; for 12h;

DOI:10.1080/00397919908085918

upstream raw materials:

(E)-1-(2-chlorophenyl)-N-(4-methoxyphenyl)methanimine

2-chloro-benzaldehyde

4-methoxy-aniline

N-(4-methoxyphenyl)-2-chlorobenzylidenimine

Downstream raw materials:

2-(2-chlorophenyl)-2-((4-methoxyphenyl)amino)acetonitrile

C₁₅H₁₃ClN₂O

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