4-AMINO-2-(METHYLTHIO)-6-PYRIMIDINOL

Base Information

• Chemical Name: 4-AMINO-2-(METHYLTHIO)-6-PYRIMIDINOL
• CAS No.: 1074-41-5
• Molecular Formula: C5H7N3OS
• Molecular Weight: 157.196
• Hs Code.: 29335990
• Mol file: 1074-41-5.mol

Synonyms:4(1H)-Pyrimidinone,6-amino-2-(methylthio)- (8CI,9CI);4-Pyrimidinol, 6-amino-2-(methylthio)-(6CI);2-(Methylthio)-4-amino-6-hydroxypyrimidine;4-Amino-6-hydroxy-2-(methylthio)pyrimidine;6-Amino-2-methylsulfanyl-3,4-dihydropyrimidin-4-one;6-Amino-2-methylthio-4-hydroxypyrimidine;6-Amino-4-hydroxy-2-(methylthio)pyrimidine;NSC 9306;

Chemical Property of 4-AMINO-2-(METHYLTHIO)-6-PYRIMIDINOL

Chemical Property:

• Appearance/Colour: White solid
• Vapor Pressure: 0.00284mmHg at 25°C
• Melting Point: 271-273 °C (dec.)
• Refractive Index: 1.707
• Boiling Point: 285.209 °C at 760 mmHg
• PKA: 8.82±0.50(Predicted)
• Flash Point: 126.29 °C
• PSA: 97.07000
• Density: 1.549 g/cm³
• LogP: 0.65520
• Storage Temp.: Refrigerator

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Amino-2-methylthio-4(3H)pyrimidinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 4-AMINO-2-(METHYLTHIO)-6-PYRIMIDINOL is a useful synthetic intermediate Intermediate in the preparation of certain antibiotics

Technology Process of 4-AMINO-2-(METHYLTHIO)-6-PYRIMIDINOL

There total 15 articles about 4-AMINO-2-(METHYLTHIO)-6-PYRIMIDINOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

dimethyl sulfate (77-78-1) + 6-amino-2-thioxo-1,2-dihydro-4(3H)-pyrimidinone (1004-40-6) → 6-amino-2-methylsulfanylpyrimidin-4(3H)-one (1074-41-5)

Guidance literature:

With sodium hydroxide;

DOI:10.1039/b211564f

Reference yield: 95.0%

4-aminothiouracil (1004-40-6) + methyl iodide (74-88-4) → 2-(Methylthio)-4-hydroxy-6-aminopyrimidine (1074-41-5)

Guidance literature:

With potassium hydroxide; at 80 ℃; for 1h; Sealed tube;

Reference yield: 95.0%

4-aminothiouracil (1004-40-6) → 2-(Methylthio)-4-hydroxy-6-aminopyrimidine (1074-41-5)

Guidance literature:

With sodium hydroxide; at 20 ℃;

DOI:10.1016/j.tet.2011.05.056

upstream raw materials:

dimethyl sulfate

methyl iodide

6-amino-2-thioxo-1,2-dihydro-4(3H)-pyrimidinone

6-Amino-2-thiouracil

Downstream raw materials:

4-[(6-amino-2-methylsulfanyl-4-oxo-4H-pyrimidin-5-ylidene)-hydrazino]-N-(5-methyl-[1,3,4]thiadiazol-2-yl)-benzenesulfonamide

4-amino-6-chloro-2-methylthiopyrimidine

6-methoxy-2-methylsulfanyl-pyrimidin-4-ylamine

6-amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one

Refernces

• 1、 Abu-Hashem,Gouda. "Synthesis and Antimicrobial Activity of Some Novel Quinoline, Chromene, Pyrazole Derivatives Bearing Triazolopyrimidine Moiety". . p. 850 - 858. Retrieved 2017.
• 2、 -. "NEW PYRIMIDINE DERIVATIVES FOR PREVENTION AND TREATMENT OF GRAM-NEGATIVE BACTERIAL INFECTION, CONTAMINATION AND FOULING". Page/Page column 110. . Retrieved 2020/10/28.