2,4-diphenylquinazoline

Base Information

• Chemical Name: 2,4-diphenylquinazoline
• CAS No.: 31730-65-1
• Molecular Formula: C20H14 N2
• Molecular Weight: 282.345
• Mol file: 31730-65-1.mol

Synonyms:2,4-Diphenylquinazoline;NSC 265383

Chemical Property of 2,4-diphenylquinazoline

Chemical Property:

• Vapor Pressure: 1.92E-05mmHg at 25°C
• Boiling Point: 373.5°Cat760mmHg
• Flash Point: 166.4°C
• Density: 1.173g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-diphenylquinazoline

There total 120 articles about 2,4-diphenylquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-chloro-2-phenylquinazoline (6484-25-9) + phenylboronic acid (98-80-6) → 2,4-diphenylquinazoline (31730-65-1)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 90 ℃;

DOI:10.1016/S0040-4039(99)01648-2

Reference yield: 95.8%

N-(2-cyanophenyl)benzamide (40288-69-5) + phenylboronic acid (98-80-6) → 2,4-diphenylquinazoline (31730-65-1)

Guidance literature:

With [2,2]bipyridinyl; palladium diacetate; trifluoroacetic acid; In tetrahydrofuran; at 60 ℃; for 28h; Reagent/catalyst; Solvent; Catalytic behavior;

Reference yield: 95.0%

N-phenyl-N'-(phenylmethyl)-benzenecarboximidamide (19376-65-9) → 2,4-diphenylquinazoline (31730-65-1)

Guidance literature:

With [bis(acetoxy)iodo]benzene; In toluene; at 120 ℃; for 1h; Reagent/catalyst; Solvent; Temperature; Time; Sealed tube;

DOI:10.1021/ol500864r

upstream raw materials:

N-(2-benzoylphenyl)benzamide

benzonitrile

N-phenyl-benzimidoyl chloride

1,4-dihydro-1,3,6-triphenyl-s-tetrazine

Downstream raw materials:

2-(2-methylphenyl)-4-phenyl-quinazoline

Refernces

• 1、 Doan, Son H.,Hussein, Mohanad A.,Nguyen, Thanh Vinh. "Tropylium-promoted Ritter reactions". supporting information. p. 8901 - 8904. Retrieved 2021/09/10.
• 2、 Chen, Zhengwang,Wen, Xiaowei,Zheng, Weiping,He, Ruolan,Chen, Dou,Cao, Dingsheng,Long, Lipeng,Ye, Min. "Acyl Cyanides as Bifunctional Reagent: Application in Copper-Catalyzed Cyanoamidation and Cyanoesterification Reaction". . p. 5691 - 5701. Retrieved 2020/04/10.