40288-69-5

Basic information

• Product Name: N-(2-cyanophenyl)benzamide
• Synonyms: N-(2-cyanophenyl)benzamide;BENZAMIDE, N-(2-CYANOPHENYL)-
• CAS NO: 40288-69-5
• Molecular Formula: C₁₄H₁₀N₂O
• Molecular Weight: 222.246
• Mol File: 40288-69-5.mol
• Article Data: 27

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-(2-cyanophenyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-cyanophenyl)benzamide(40288-69-5)
• EPA Substance Registry System: N-(2-cyanophenyl)benzamide(40288-69-5)

Safety Data

• Hazardous Substances Data: 40288-69-5(Hazardous Substances Data)

Usage

General Description

N-(2-cyanophenyl)benzamide is a chemical compound with the molecular formula C15H11N3O. It is a benzamide derivative with a cyanophenyl group attached to the nitrogen atom of the benzamide moiety. N-(2-cyanophenyl)benzamide is widely used in medicinal and pharmaceutical chemistry as a building block for the synthesis of various biologically active molecules. It is also used as an intermediate in organic synthesis and as a reagent in chemical research. N-(2-cyanophenyl)benzamide has diverse applications in the field of drug discovery and development, making it an important chemical in the pharmaceutical industry.

Upstream product

• 93-58-3 benzoic acid methyl ester 
• 1885-29-6 anthranilic acid nitrile 
• 613-90-1 benzoyl cyanide 
• 615-43-0 2-iodophenylamine 
• 98-86-2 acetophenone 
• 948-65-2 2-phenyl-indole 
• 4676-99-7 3-hydroxyimino-2-phenyl-3H-indole 
• 4387-36-4 2-iodobenzonitrile 
• 55-21-0 benzamide 
• 93-97-0 benzoic acid anhydride 
• 108-86-1 bromobenzene 
• 13939-06-5 molybdenum hexacarbonyl 
• 100-52-7 benzaldehyde 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1022-46-4 2-phenyl-4H-3,1-benzoxazin-4-one 
• 16107-82-7 4-(4-methylphenyl)-2-phenyl-quinazoline 
• 1229609-91-9 4-(4-fluoro-phenyl)-2-phenyl-quinazoline 
• 99682-89-0 4-(4-chlorophenyl)-2-phenylquinazoline 
• 15437-26-0 N-(2-cyanophenyl)benzimidoyl chloride 
• 1022-45-3 2-phenyl-4(3H)-quinazolinone 
• 31730-65-1 2,4-diphenylquinazoline 
• 133993-38-1 5,6,11,12-tetrahydroindolo<3.2-c><2>benzoazepin-6,11-dione 
• 133993-39-2 12-Benzoyl-5,12-dihydro-5,12-diaza-dibenzo[a,f]azulene-6,11-dione 

Relevant articles and documents

Tert-Butyl Nitrite Mediated Synthesis of Fluorinated O-Alkyloxime Ether Derivatives

A tert-butyl nitrite (TBN)-mediated synthesis of fluorinated O-alkyloxime ether derivatives with bromodifluoroalkyl reagents as the fluorine sources has been developed. A variety of halodifluorinated compounds were found compatible, delivering the desired

Acyl Cyanides as Bifunctional Reagent: Application in Copper-Catalyzed Cyanoamidation and Cyanoesterification Reaction

Cu-catalyzed domino decyanation and cyanation reaction of acyl cyanides with amines or alcohols have been developed. The cyano sources were generated in situ via C-CN cleavage yielding the corresponding cyano substituted amides or esters in moderate to excellent yields. This approach features a cheap copper catalyst, domino decyanation and cyanation reaction, readily available starting materials, broad substrate scope, operational simplicity, and the potential for further transformation of the cyano group.

Combined Cyanoborylation, C-H Activation Strategy for Styrene Functionalization

A one-pot multicomponent copper-catalyzed protocol for borylation/ortho-cyanation of styrene derivatives followed by a Suzuki-Miyaura coupling provides a platform to explore the factors that control the selectivity between distal or proximal functionalization of arenes. The development of divergent nitrile-directed C-H functionalization (acetoxylation, pivalation, and methoxylation) offers an effective approach to rapidly increase synthetic complexity. Finally, the development of a mild reductive decyanation allows a traceless method to access functionalized biaryl motifs.