40288-69-5

Usage

Uses

Used in Medicinal and Pharmaceutical Chemistry:
N-(2-cyanophenyl)benzamide is utilized as a building block for the synthesis of biologically active molecules, contributing to the development of new drugs and therapeutic agents.
Used in Organic Synthesis:
As an intermediate in organic synthesis, N-(2-cyanophenyl)benzamide plays a crucial role in the preparation of complex organic compounds and contributes to the advancement of organic chemistry.
Used in Chemical Research:
N-(2-cyanophenyl)benzamide serves as a reagent in chemical research, aiding in the investigation of various chemical reactions and processes, thereby enhancing our understanding of chemical mechanisms and properties.
Used in Drug Discovery and Development:
With its diverse applications in the field of drug discovery and development, N-(2-cyanophenyl)benzamide is an important chemical that facilitates the identification and optimization of potential drug candidates, ultimately contributing to the creation of novel therapeutic agents for various diseases and conditions.

Upstream product

• 4676-99-7 2-phenyl-indol-3-one oxime 
• 98-88-4 benzoyl chloride 
• 1885-29-6 anthranilic acid nitrile 
• 4676-99-7 3-Hydroxyimino-2-phenyl-3H-indole 
• 100-52-7 benzaldehyde 
• 108-86-1 bromobenzene 
• 13939-06-5 molybdenum hexacarbonyl 
• 4387-36-4 2-iodobenzonitrile 
• 55-21-0 benzamide 
• 4676-99-7 3-hydroxyimino-2-phenyl-3H-indole 
• 948-65-2 2-phenyl-indole 
• 98-86-2 acetophenone 
• 93-58-3 benzoic acid methyl ester 
• 613-90-1 benzoyl cyanide 

Downstream Products

• 26060-03-7 4-Methoxy-2-phenylquinazoline 
• 18543-22-1 2-benzoylaminobenzamide 
• 5585-14-8 3,4-diphenyl-furazan 2-oxide 
• 93245-17-1 N-[2-(3-Phenyl-[1,2,4]oxadiazol-5-yl)-phenyl]-benzamide 
• 31730-65-1 2,4-diphenylquinazoline 
• 6483-99-4 2-phenyl-3,4-dihydroquinazolin-4-thione 
• 13961-48-3 2,3-diphenyl-2H-quinazoline-4-thione 
• 49699-38-9 2-phenyl-3-p-tolyl-3H-quinazoline-4-thione 
• 396716-35-1 2-phenyl-4-iminobenzo[d][1,3]thiazine 
• 53628-20-9 3-(4-chloro-phenyl)-2-phenyl-3H-quinazoline-4-thione 
• 400604-97-9 N³,N³-(3-oxapentan-1,5-diyl)-N¹-(2-phenyl-3,4-dihydroquinazolin-4-yliden)thiourea 
• 400605-03-0 1,1-dibutyl-3-[(2-cyanophenylimino)phenylmethyl] thiourea 
• 1149762-96-8 di-tert-butyl 2-[N-(2-cyanophenyl)benzamido]-3-(triphenylphosphanylidene)butanedioate 
• 1149762-95-7 dimethyl 2-[N-(2-cyanophenyl)benzamido]-3-(triphenylphosphanylidene)butanedioate 

Relevant academic research and scientific papers

Tert-Butyl Nitrite Mediated Synthesis of Fluorinated O-Alkyloxime Ether Derivatives

A tert-butyl nitrite (TBN)-mediated synthesis of fluorinated O-alkyloxime ether derivatives with bromodifluoroalkyl reagents as the fluorine sources has been developed. A variety of halodifluorinated compounds were found compatible, delivering the desired

Manganese Catalyzed Direct Amidation of Esters with Amines

The transition metal catalyzed amide bond forming reaction of esters with amines has been developed as an advanced approach for overcoming the shortcomings of traditional methods. The broad scope of substrates in transition metal catalyzed amidations remains a challenge. Here, a manganese(I)-catalyzed method for the direct synthesis of amides from a various number of esters and amines is reported with unprecedented substrate scope using a low catalyst loading. A wide range of aromatic, aliphatic, and heterocyclic esters, even in fatty acid esters, reacted with a diverse range of primary aryl amines, primary alkyl amines, and secondary alkyl amines to form amides. It is noteworthy that this approach provides the first example of the transition metal catalyzed amide bond forming reaction from fatty acid esters and amines. The acid-base mechanism for the manganese(I)-catalyzed direct amidation of esters with amines was elucidated by DFT calculations.

Synthesis of 2-Amino-1,3-dienes from Propargyl Carbonates via Palladium-Catalyzed Carbon-Nitrogen Bond Formation

A catalytic method to synthesize 1,3,-dienes from propargylic precursors is reported. This palladium-catalyzed carbon-nitrogen bond-forming reaction furnishes 2-amino-1,3-dienes in excellent yields (up to 98%) and shows a broad tolerance to functional group diversity. The reaction has been demonstrated for over 30 amine substrates, including anilines and indoles, and proceeds under mild neutral conditions. The resulting 1,3-dienes are of great synthetic interest because of their further reaction potential.

Combined Cyanoborylation, C-H Activation Strategy for Styrene Functionalization

A one-pot multicomponent copper-catalyzed protocol for borylation/ortho-cyanation of styrene derivatives followed by a Suzuki-Miyaura coupling provides a platform to explore the factors that control the selectivity between distal or proximal functionalization of arenes. The development of divergent nitrile-directed C-H functionalization (acetoxylation, pivalation, and methoxylation) offers an effective approach to rapidly increase synthetic complexity. Finally, the development of a mild reductive decyanation allows a traceless method to access functionalized biaryl motifs.

Acyl Cyanides as Bifunctional Reagent: Application in Copper-Catalyzed Cyanoamidation and Cyanoesterification Reaction

Cu-catalyzed domino decyanation and cyanation reaction of acyl cyanides with amines or alcohols have been developed. The cyano sources were generated in situ via C-CN cleavage yielding the corresponding cyano substituted amides or esters in moderate to excellent yields. This approach features a cheap copper catalyst, domino decyanation and cyanation reaction, readily available starting materials, broad substrate scope, operational simplicity, and the potential for further transformation of the cyano group.

Method for preparing derivatives of benzamide under microwave condition in aqueous phase

The invention discloses a method for preparing derivatives of benzamide under a microwave condition in an aqueous phase. A coupling reaction is carried out between substituted benzoic acid and amine under the microwave condition in the aqueous phase. The method for preparing the derivatives of benzamide is environmentally friendly, easy and convenient to operate, safe, low in cost and efficient. Compared with the prior art, the method can be applicable to a large number of functional groups, is high in yield, produces fewer by-products, and further is easy to operate, safe, low in cost and environmentally friendly. A formula is shown in the description.

Method for synthesizing amide compound through photocatalysis in water phase

The invention discloses a method for synthesizing an amide compound through photocatalysis in a water phase. The method comprises the following steps: putting catalysis amounts of a free radical initiator, an amine derivative, a carboxylic acid derivative, a phase transfer catalyst, an inorganic base and water into a reaction container, carrying out a reaction in a photocatalysis reaction instrument at certain power under a room temperature condition, after a certain time, carrying out extraction by using a small amount of ethyl acetate, and carrying out recrystallization, so as to obtain theamide compound, wherein the free radical initiator is eosin, methyl orange, sodium persulfate, ammonium persulfate or potassium peroxodisulfate, the phase transfer catalyst is tetrabutylammonium bromide, and the power of the photocatalytic reaction instrument is 5W. By adopting the method disclosed by the invention, toxic thionyl chloride or phosphorus oxychloride is not needed for a chlorinationreaction, water is adopted as a solvent, a novel photocatalysis method is used, and the amide compound with a high yield can be prepared through a room-temperature reaction for 2-5 hours with an incandescent light bulb of 5W, and in addition, the method is simple in aftertreatment, and low in cost and is an ideal green synthesis method of amide compounds.

Synthesizing method of drug intermediate quinazoline compound

The invention relates to a quinazoline compound as shown in formula (5) and capable of being used as a drug intermediate and a synthesizing method of the quinazoline compound. The synthesizing methodhas the advantages that the method is completed through

Synthesis method of nitrogen-containing heterocyclic drug intermediates

The invention relates to nitrogen-containing heterocyclic compounds which can be used as drug intermediates and are shown in the following formula (5) in the description and further provides a synthesis method of the nitrogen-containing heterocyclic compo

Fused heterocyclic pharmaceutical intermediate synthesis method

The present invention relates to a fused heterocyclic compound capable of being used as a pharmaceutical intermediate and represented by the following formula (5) defined in the specification, and provides a synthesis method of the fused heterocyclic comp