2-Bromomethylquinoline

Base Information

• Chemical Name: 2-Bromomethylquinoline
• CAS No.: 5632-15-5
• Molecular Formula: C10H8BrN
• Molecular Weight: 222.084
• Hs Code.: 2933499090
• Mol file: 5632-15-5.mol

Synonyms:2-(Bromomethyl)quinoline;a-Bromoquinaldine;2-bromomethylquinoline;

Chemical Property of 2-Bromomethylquinoline

Chemical Property:

• Vapor Pressure: 2.4E-07mmHg at 25°C
• Melting Point: 169 °C
• Refractive Index: 1.642
• Boiling Point: 300.495 °C at 760 mmHg
• PKA: 3.19±0.48(Predicted)
• Flash Point: 135.535 °C
• PSA: 12.89000
• Density: 1.518 g/cm³
• LogP: 3.12970
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-(Bromomethyl)quinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,N,Xn
• Statements: 22-41-51/53
• Safety Statements: 26-39-61

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2-Bromomethylquinoline

There total 3 articles about 2-Bromomethylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-methylquinoline (91-63-4) → quinolin-2-ylmethylbromide (5632-15-5) + 2-(dibromomethyl)quinoline (53867-81-5)

Guidance literature:

With N-Bromosuccinimide; Perbenzoic acid; In tetrachloromethane; at 70 ℃; for 12h;

DOI:10.1016/j.carres.2011.06.028

Reference yield: 30.0%

2-methylquinoline (91-63-4) + benzylamine (100-46-9) → quinolin-2-ylmethylbromide (5632-15-5) + 1-phenylimidazo<1,5-a>quinoline

Guidance literature:

With oxygen; acetic acid; copper(ll) bromide; In chlorobenzene; at 120 ℃; for 0.25h; under 760.051 Torr; Catalytic behavior;

DOI:10.1002/ejoc.201800628

Reference yield: 15.5%

2-methylquinoline (91-63-4) + benzylamine (100-46-9) → quinoline 2-carbaldehyde (5470-96-2) + quinolin-2-ylmethylbromide (5632-15-5) + 1-phenylimidazo<1,5-a>quinoline

Guidance literature:

With oxygen; lithium bromide; copper(ll) bromide; In chlorobenzene; at 120 ℃; for 1.5h; under 760.051 Torr;

DOI:10.1021/acs.joc.6b02117

upstream raw materials:

2-methylquinoline

benzylamine

Downstream raw materials:

2-(4-nitro-phenoxymethyl)-quinoline

2-p-tolyloximethyl-quinoline

quinolin-2-ylmethyl benzoate

2-[(4-nitro-phenylsulfanyl)-methyl]-quinoline

Refernces

• 1、 Tan, Zhenda,Zhao, He,Zhou, Changjian,Jiang, Huanfeng,Zhang, Min. "Aerobic Copper-Catalyzed Halocyclization of Methyl N-Heteroaromatics with Aliphatic Amines: Access to Functionalized Imidazo-Fused N-Heterocycles". . p. 9939 - 9946. Retrieved 2016/11/02.