53867-81-5

Basic information

• Product Name: 2-(DIBROMOMETHYL)QUINOLINE
• Synonyms: 2-(DIBROMOMETHYL)QUINOLINE;α,α-Dibromoquinaldine
• CAS NO: 53867-81-5
• Molecular Formula: C₁₀H₇Br₂N
• Molecular Weight: 300.98
• Mol File: 53867-81-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 120 °C
• Boiling Point: 337.2°Cat760mmHg
• Flash Point: 157.8°C
• Appearance: /
• Density: 1.878g/cm³
• Vapor Pressure: 0.000208mmHg at 25°C
• Refractive Index: 1.709
• PKA: 1.96±0.61(Predicted)
• CAS DataBase Reference: 2-(DIBROMOMETHYL)QUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(DIBROMOMETHYL)QUINOLINE(53867-81-5)
• EPA Substance Registry System: 2-(DIBROMOMETHYL)QUINOLINE(53867-81-5)

Safety Data

• Hazardous Substances Data: 53867-81-5(Hazardous Substances Data)

Usage

Functional group

Dibromomethyl (two bromine atoms attached to a methyl group)

Potential applications

Organic synthesis, chemical research, production of pharmaceuticals and agrochemicals

Usage

Reagent, building block in synthesis of heterocyclic compounds, precursor for complex organic molecules

Hazards

Potential toxicity and hazardous nature, requires careful handling.

InChI:InChI=1/C10H7Br2N/c11-10(12)9-6-5-7-3-1-2-4-8(7)13-9/h1-6,10H

Upstream product

• 91-63-4 2-methylquinoline 
• 91850-85-0 <1,2,3>triazolo<1,5-a>quinoline-3-carboxylic acid 
• 91850-86-1 3-(N,N-diethylcarbamoyl)<1,2,3>triazolo<1,5-a>quinoline 
• 235-21-2 [1,2,3]triazalo[3,5-α]quinolone 
• 613-53-6 2-tribromomethyl-quinoline 

Downstream Products

• 5470-96-2 quinoline 2-carbaldehyde 
• 88023-05-6 2-[2]quinolylmethyl-acetoacetic acid ethyl ester 
• 39111-94-9 3-(quinoline-2-yl)propanoic acid 
• 1613-34-9 2-ethylquinoline 
• 36680-23-6 1,1-cyclohexyliden-2-(2-quinolyl)ethylene 

Relevant articles and documents

Copper(II) catalyzed heterobenzylic C(sp3)-H activation: Two efficient halogenation methodologies towards heterobenzyl halides

Two practical and simple synthetic methodologies towards various heterobenzyl halides were developed. A series of 2-halomethylquinolines were readily prepared by the one-pot reaction of 2-methylquinolines with CuX (X = I, Br, Cl) and TBHP in CH3CN. A large variety of heterobenzyl iodides, including 2-iodomethylquinolines, 2-iodomethylquinoxalines, 2-iodiomethylbenzooxazole, and 2-iodiomethylbenzothiazole, were efficiently synthesized by one-pot reaction of 2-methylheterocycles with iodine in the presence of CuSO4·5H2O in CH3CN.

Iron-catalyzed coupling reaction between 1,1-dichloro-1-alkenes and Grignard reagents

This letter reports the coupling reaction of Grignard reagents with 1,1-dichloro-1-alkenes in the presence of the environmentally friendly iron(III) catalyst. This non-toxic procedure is general and provides the di-coupled products as the major compounds. The scope and limitations of this new reaction are described.

Studies on tertiary amine oxides. XLVII. Reaction of quinoline 1 oxide derivatives with cyanogen bromide

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