N-(4-chlorophenyl)-4-(4-fluorophenyl)-1,3-thiazol-2-amine

Base Information

Chemical Name:N-(4-chlorophenyl)-4-(4-fluorophenyl)-1,3-thiazol-2-amine
CAS No.:61383-56-0
Molecular Formula:C15H10ClFN2S
Molecular Weight:304.775
Hs Code.:
DSSTox Substance ID:DTXSID60355205
Wikidata:Q82133951
ChEMBL ID:CHEMBL3134314

Synonyms:61383-56-0;STK125549;2-Thiazolamine, N-(4-chlorophenyl)-4-(4-fluorophenyl)-;N-(4-chlorophenyl)-4-(4-fluorophenyl)-1,3-thiazol-2-amine;CBMicro_016688;CHEMBL3134314;DTXSID60355205;AKOS002663253

Suppliers and Price of N-(4-chlorophenyl)-4-(4-fluorophenyl)-1,3-thiazol-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 0 raw suppliers

Chemical Property of N-(4-chlorophenyl)-4-(4-fluorophenyl)-1,3-thiazol-2-amine

Chemical Property:

PSA：53.16000
LogP:5.41920
XLogP3:5.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:304.0237254
Heavy Atom Count:20
Complexity:304

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)Cl)F

Technology Process of N-(4-chlorophenyl)-4-(4-fluorophenyl)-1,3-thiazol-2-amine

There total 3 articles about N-(4-chlorophenyl)-4-(4-fluorophenyl)-1,3-thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 403-29-2
2-bromo-4'-fluoroacetophenone

: 3696-23-9
N-(4-chlorophenyl)thiourea

: 61383-56-0
N-(4-chlorophenyl)-4-(4-fluorophenyl)thiazol-2-amine

Guidance literature:: 2-bromo-4'-fluoroacetophenone; N-(4-chlorophenyl)thiourea; In ethanol; at 80 ℃; for 1h;

With sodium carbonate; In dichloromethane; water; for 0.25h;
DOI:10.1039/c3md00226h

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 61383-56-0
N-(4-chlorophenyl)-4-(4-fluorophenyl)thiazol-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide / ethyl acetate / 40 °C

2: triethylamine / ethanol / Reflux

With N-Bromosuccinimide; triethylamine; In ethanol; ethyl acetate;