N-methyl-2-Thiazolamine

Base Information

• Chemical Name: N-methyl-2-Thiazolamine
• CAS No.: 6142-06-9
• Molecular Formula: C4H6N2S
• Molecular Weight: 114.171
• Hs Code.: 2934100090
• European Community (EC) Number: 835-906-2
• DSSTox Substance ID: DTXSID90474776
• Nikkaji Number: J1.613.143A
• Wikidata: Q82304903
• Mol file: 6142-06-9.mol

Synonyms:N-methyl-2-Thiazolamine;6142-06-9;N-METHYLTHIAZOL-2-AMINE;N-methyl-1,3-thiazol-2-amine;2-Thiazolamine, N-methyl-;MFCD09966061;Methyl-thiazol-2-yl-amine;2-methylaminothiazole;2-(methylamino)thiazole;2-(methyl-amino)thiazole;N-Methyl-2-aminothiazole;SCHEMBL84740;SCHEMBL13865327;DTXSID90474776;DWVCPSQPTSNMRX-UHFFFAOYSA-N;AMY28978;AKOS005199446;CS-W006616;GS-4213;SY104581;FT-0704901;EN300-36374;Z336483296

Chemical Property of N-methyl-2-Thiazolamine

Chemical Property:

• Vapor Pressure: 1.202mmHg at 25°C
• Refractive Index: 1.624
• Boiling Point: 174.508 °C at 760 mmHg
• PKA: 5.38±0.10(Predicted)
• Flash Point: 59.341 °C
• PSA: 53.16000
• Density: 1.246 g/cm³
• LogP: 1.25780
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 114.02516937
• Heavy Atom Count: 7
• Complexity: 57.7

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Methyl-2-thiazolamine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CNC1=NC=CS1

Technology Process of N-methyl-2-Thiazolamine

There total 8 articles about N-methyl-2-Thiazolamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(p-tolylthiomethyl)aminothiazole (78508-29-9) → 2-methylaminothiazole (6142-06-9)

Guidance literature:

With sodium tetrahydroborate; In 1,2-dimethoxyethane; for 0.75h; Heating;

DOI:10.1039/P19810001569

Reference yield: 85.0%

N-(thiazol-2-yl)formamide (25602-39-5) → 2-methylaminothiazole (6142-06-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating;

DOI:10.1081/SCC-100105662

Reference yield: 67.0%

2-bromo-1,3-thiazole (3034-53-5,215777-74-5) + methylamine (74-89-5) → 2-methylaminothiazole (6142-06-9)

Guidance literature:

In ethanol; at 120 ℃; for 2h; under 7500.75 Torr;

upstream raw materials:

1,2-dichloroethyl acetate

1-(methyl)-thiourea

1,2-dichloro-2-ethoxyethane

N-methylisothiourea

Downstream raw materials:

4-nitro-benzenesulfonic acid-(methyl-thiazol-2-yl-amide)

4-acetylamino-N-methyl-N-thiazol-2-yl-benzenesulfonamide

anhydro-7-Hydroxy-8-methyl-5-oxo-6-phenyl-2H-thiazolo<3,2-a>pyrimidinium hydroxide

1-Methyl-3-(4-nitro-phenyl)-1-thiazol-2-yl-urea

Refernces

• 1、 Daszkiewicz,Koterzyna,Kyziol. "Synthesis and rearrangement of N-methyl-N-(2-thiazolyl)-nitramine". . p. 2921 - 2927. Retrieved 2007/10/03.
• 2、 Walchshofer,Minjat,Tinland,et al.. "Study of structural parameters related to anthelminthic activity of thiazole derivatives". . p. 59 - 64. Retrieved 2007/10/02.