5(4H)-Oxazolone, 2,4-diphenyl-

Base Information

• Chemical Name: 5(4H)-Oxazolone, 2,4-diphenyl-
• CAS No.: 28687-81-2
• Molecular Formula: C15H11 N O2
• Molecular Weight: 237.258
• Hs Code.: 2934999090
• Mol file: 28687-81-2.mol

Synonyms:2-Oxazolin-5-one,2,4-diphenyl- (8CI); 2,4-Diphenyl-2-oxazolin-5-one;2,4-Diphenyl-4H-oxazol-5-one; 2,4-Diphenyl-4H-oxazolin-5-one;2,4-Diphenyloxazol-5(4H)-one; 2,4-Diphenyloxazolin-5-one; NSC 10171

Chemical Property of 5(4H)-Oxazolone, 2,4-diphenyl-

Chemical Property:

• Vapor Pressure: 1.26E-05mmHg at 25°C
• Melting Point: 100 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 368.5°Cat760mmHg
• PKA: 1.78±0.40(Predicted)
• Flash Point: 169.2°C
• PSA: 38.66000
• Density: 1.2g/cm³
• LogP: 2.16690

Purity/Quality:

99.3% ^*data from raw suppliers

2,4-Diphenyl-1,3-oxazol-5(4H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5(4H)-Oxazolone, 2,4-diphenyl-

There total 6 articles about 5(4H)-Oxazolone, 2,4-diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-benzoyl-2-phenylglycine (29670-63-1) → 2,4-diphenyl-4H-oxazol-5-one (28687-81-2,719263-73-7)

Guidance literature:

With trifluoroacetic anhydride; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmc.2009.03.002 DOI:10.1021/jm8013162

Reference yield:

benzoyl chloride (98-88-4) → 2,4-diphenyl-4H-oxazol-5-one (28687-81-2,719263-73-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In dichloromethane; water;

DOI:10.1080/00397911.2011.644846

Reference yield:

→ 2,4-diphenyl-4H-oxazol-5-one (28687-81-2,719263-73-7)

Guidance literature:

With acetic anhydride;

upstream raw materials:

N-benzoyl-2-phenylglycine

benzoyl chloride

Downstream raw materials:

2,4-Diphenyl-4-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-4H-oxazol-5-one

N-(2-Furan-2-yl-1-methyl-4-oxo-3-phenyl-azetidin-3-yl)-benzamide

2,4,4-triphenyl-Δ²-oxazolin-5-one

2,4-diphenyl-4-(4-methoxyphenyl)-4H-oxazol-5-one