Benzoic acid, 4-chloro-2-(2-propenyl)-

Base Information

• Chemical Name: Benzoic acid, 4-chloro-2-(2-propenyl)-
• CAS No.: 61436-77-9
• Molecular Formula: C10H9ClO2
• Molecular Weight: 196.633
• Mol file: 61436-77-9.mol

Synonyms:

Chemical Property of Benzoic acid, 4-chloro-2-(2-propenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 4-chloro-2-(2-propenyl)-

There total 3 articles about Benzoic acid, 4-chloro-2-(2-propenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-bromo-4-chlorobenzoic acid (936-08-3) + allyl bromide (106-95-6) → 2-allyl-4-chlorobenzoic acid (61436-77-9)

Guidance literature:

2-bromo-4-chlorobenzoic acid; With methylmagnesium bromide; In tetrahydrofuran; at -30 ℃; for 0.0833333h; Inert atmosphere;

With isopropylmagnesium chloride; In tetrahydrofuran; at -30 ℃; for 1h; Inert atmosphere;

allyl bromide; Further stages;

DOI:10.1002/chem.201403561

Reference yield:

4-chloro-2-iodobenzoic acid (13421-13-1) + allyl bromide (106-95-6) → 2-allyl-4-chlorobenzoic acid (61436-77-9)

Guidance literature:

4-chloro-2-iodobenzoic acid; With copper(I) cyanide di(lithium chloride); isopropylmagnesium chloride; In tetrahydrofuran; at -40 ℃; for 1h;

allyl bromide; In tetrahydrofuran; at -40 - 25 ℃;

With lithium hydroxide monohydrate; at 25 ℃;

DOI:10.1039/d0ob00303d

Reference yield:

→ 2-allyl-4-chlorobenzoic acid (61436-77-9)

Guidance literature:

2-Jod-4-chlorbenzoesaeure-Na-Salz, ?-Allylnickelbromid;

DOI:10.1021/jo00428a013

upstream raw materials:

2-bromo-4-chlorobenzoic acid

allyl bromide

4-chloro-2-iodobenzoic acid

Refernces

• 1、 Chuc, Le Thi Ngoc,Hou, Duen-Ren,Nguyen, Thi Anh Hong. "Acid-base-sensitive allylic oxidation of 2-allylbenzoic acids to form phthalides". . p. 2758 - 2768. Retrieved 2020/04/17.