Benzeneacetic acid, a,2-dihydroxy-

Base Information

• Chemical Name: Benzeneacetic acid, a,2-dihydroxy-
• CAS No.: 1678-71-3
• Molecular Formula: C8H8 O4
• Molecular Weight: 168.149
• Mol file: 1678-71-3.mol

Synonyms:Mandelicacid, o-hydroxy- (6CI,7CI,8CI); NSC 126698; o-Hydroxymandelic acid

Chemical Property of Benzeneacetic acid, a,2-dihydroxy-

Chemical Property:

• Boiling Point: 397.5°Cat760mmHg
• Flash Point: 208.4°C
• Density: 1.48g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetic acid, a,2-dihydroxy-

There total 15 articles about Benzeneacetic acid, a,2-dihydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Glyoxilic acid (298-12-4) + phenol (108-95-2,27073-41-2) → 2-hydroxymandelic acid (1678-71-3)

Guidance literature:

With aluminum(III) sulfate; tributyl-amine; water; at 50 ℃; for 8h;

Reference yield: 76.9%

Glyoxilic acid (298-12-4) + phenol (108-95-2,27073-41-2) → 4-hydroxymandelic acid (1198-84-1) + 2-hydroxymandelic acid (1678-71-3)

Guidance literature:

With zinc(II) oxide; In water; at 70 ℃; for 3h;

Reference yield:

MANDELIC ACID (611-71-2,611-72-3,17199-29-0,90-64-2) → 4-hydroxymandelic acid (1198-84-1) + (R,S)3-hydroxymandelic acid (17119-15-2,53623-77-1) + 2-hydroxymandelic acid (1678-71-3) + benzaldehyde (100-52-7) + benzoic acid (65-85-0,8013-63-6)

Guidance literature:

With ferrous perchlorate; dihydrogen peroxide; In water; at 25 ℃; Product distribution; Mechanism; pH 1-2.5, other oxidant;

DOI:10.1021/ja00369a005

upstream raw materials:

(2-hydroxyphenyl)oxoacetic acid

2-amino-DL-mandelic acid

MANDELIC ACID

Glyoxilic acid

Downstream raw materials:

2-Hydroxyphenylacetic acid

methyl 2-hydroxymandelate

Refernces

• 1、 -. "QUINONE METHIDE ANALOG SIGNAL AMPLIFICATION". Page/Page column 75. . Retrieved 2015/09/28.
• 2、 -. "Method of preparing 2- and 4-hydroxymandelic acid". Page column 6. . Retrieved 2008/06/13.