6-Hydroxy-3,5,5-trimethyl-2-cyclohexen-1-one

Base Information

• Chemical Name: 6-Hydroxy-3,5,5-trimethyl-2-cyclohexen-1-one
• CAS No.: 61592-66-3
• Molecular Formula: C9H14O2
• Molecular Weight: 154.209
• DSSTox Substance ID: DTXSID30454552
• Nikkaji Number: J531.609J
• Mol file: 61592-66-3.mol

Synonyms:6-hydroxy-3,5,5-trimethyl-2-cyclohexen-1-one;61592-66-3;6-hydroxy-3,5,5-trimethylcyclohex-2-en-1-one;2-Cyclohexen-1-one, 6-hydroxy-3,5,5-trimethyl-;DTXSID30454552

Chemical Property of 6-Hydroxy-3,5,5-trimethyl-2-cyclohexen-1-one

Chemical Property:

• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 154.099379685
• Heavy Atom Count: 11
• Complexity: 214

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=O)C(C(C1)(C)C)O

Technology Process of 6-Hydroxy-3,5,5-trimethyl-2-cyclohexen-1-one

There total 7 articles about 6-Hydroxy-3,5,5-trimethyl-2-cyclohexen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(+/-)-6-acetoxy-3,3,5-trimethylcyclohex-2-en-1-one (19019-49-9) → 6-hydroxy-3,5,5-trimethyl-2-cyclohexen-1-one (61592-66-3)

Guidance literature:

With lithium hydroxide; In methanol; at 25 ℃; for 1h;

DOI:10.1021/jo00060a040

Reference yield: 67.0%

tert-butyl (4,4-dimethylhepta-1,6-diyn-3-yl) carbonate → 6-hydroxy-3,5,5-trimethyl-2-cyclohexen-1-one (61592-66-3)

Guidance literature:

With silver hexafluoroantimonate; 2-(di-tert-butylphosphino)-1,1'-biphenylgold(I) chloride; In 1,2-dichloro-ethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acs.orglett.6b01898 DOI:10.1021/acs.orglett.6b02509

Reference yield: 15.0%

methanol (67-56-1) + 3,5,5-Trimethylcyclohex-2-en-1-one (78-59-1) → 6-hydroxy-3,5,5-trimethyl-2-cyclohexen-1-one (61592-66-3) + 6-hydroxy-3-methoxymethyl-5,5-dimethyl-2-cyclohexenone (111681-11-9)

Guidance literature:

With potassium hydroxide; [bis(acetoxy)iodo]benzene; for 0.5h; Ambient temperature;

upstream raw materials:

(+/-)-6-acetoxy-3,3,5-trimethylcyclohex-2-en-1-one

methanol

3,5,5-Trimethylcyclohex-2-en-1-one

3-hydroxy-4,4-dimethyl-hepta-1,6-diyne

Downstream raw materials:

(+/-)-6-acetoxy-3,3,5-trimethylcyclohex-2-en-1-one

2-hydroxy-3,3,5-trimethylcyclohexan-1-one

2,2,4-trimethylcyclopentan-1-one

2,2,4-trimethyl-6-phenylselanyl-cyclohexanone