4-Morpholineacetic acid, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, dihydrochloride, exo-

Base Information

• Chemical Name: 4-Morpholineacetic acid, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, dihydrochloride, exo-
• CAS No.: 87168-38-5
• Molecular Formula: C₁₄H₂₄N₂O₃*2ClH
• Molecular Weight: 341.278
• DSSTox Substance ID: DTXSID401007374
• Mol file: 87168-38-5.mol

Synonyms:4-Morpholineacetic acid, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, dihydrochloride, exo-;87168-38-5;endo-8-Methyl-8-azabicyclo(3.2.1)oct-3-yl-4-morpholineacetate dihydrochloride;exo-8-Methyl-8-azabicyclo(3.2.1)oct-3-yl-4-morpholineacetate dihydrochloride;(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-morpholin-4-ylacetate;dihydrochloride;4-Morpholineacetic acid, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, dihydrochloride, endo-;C14-H24-N2-O3.2Cl-H;87168-39-6;C14H24N2O3.2ClH;DTXSID401007374;LS-92357;LS-92358;8-Methyl-8-azabicyclo[3.2.1]octan-3-yl (morpholin-4-yl)acetate--hydrogen chloride (1/2)

Chemical Property of 4-Morpholineacetic acid, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, dihydrochloride, exo-

Chemical Property:

• Vapor Pressure: 1.67E-05mmHg at 25°C
• Boiling Point: 364.5°Cat760mmHg
• Flash Point: 174.2°C
• Density: g/cm³
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 340.1320481
• Heavy Atom Count: 21
• Complexity: 317

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C2CCC1CC(C2)OC(=O)CN3CCOCC3.Cl.Cl

Technology Process of 4-Morpholineacetic acid, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, dihydrochloride, exo-

There total 4 articles about 4-Morpholineacetic acid, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, dihydrochloride, exo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.2%

morpholine (110-91-8,99108-56-2) + Chloro-acetic acid (1R,3S,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester; hydrochloride → Morpholin-4-yl-acetic acid (1R,3S,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester; hydrochloride (87168-38-5,87168-39-6)

Guidance literature:

In ethanol; for 8h; Heating;

DOI:10.1007/BF00765640

Reference yield: 58.6%

morpholine (110-91-8,99108-56-2) + Chloro-acetic acid (1R,3R,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester; hydrochloride (438581-53-4) → Morpholin-4-yl-acetic acid (1R,3R,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester; hydrochloride (87168-38-5,87168-39-6)

Guidance literature:

In ethanol; for 8h; Heating;

DOI:10.1007/BF00765640

Reference yield:

3-tropanol (120-29-6) → Morpholin-4-yl-acetic acid (1R,3R,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester; hydrochloride (87168-38-5,87168-39-6)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 4 h / Heating

2: 58.6 percent / ethanol / 8 h / Heating

In ethanol; toluene;

DOI:10.1007/BF00765640

upstream raw materials:

morpholine

Chloro-acetic acid (1R,3R,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester; hydrochloride

3-tropanol

pseudotropine