Benzenepropanenitrile, 2-bromo-

Base Information

• Chemical Name: Benzenepropanenitrile, 2-bromo-
• CAS No.: 61698-07-5
• Molecular Formula: C9H8BrN
• Molecular Weight: 210.073
• Mol file: 61698-07-5.mol

Synonyms:Benzenepropanenitrile,2-bromo;

Chemical Property of Benzenepropanenitrile, 2-bromo-

Chemical Property:

• PSA: 23.79000
• LogP: 2.90528

Purity/Quality:

98%Min ^*data from raw suppliers

3-(2-bromophenyl)propanenitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenepropanenitrile, 2-bromo-

There total 10 articles about Benzenepropanenitrile, 2-bromo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

3-(2-bromo-phenyl)-acrylonitrile (178809-30-8) → 3-(2-bromo-phenyl)-propionitrile (61698-07-5)

Guidance literature:

With sodium tetrahydroborate; In methanol; 1,2-dimethoxyethane; at 70 ℃; for 15h;

DOI:10.1016/0040-4020(96)00266-9

Reference yield: 52.0%

acetonitrile (75-05-8,26809-02-9) + 1-Bromo-2-bromomethyl-benzene (3433-80-5) → 3-(2-bromo-phenyl)-propionitrile (61698-07-5)

Guidance literature:

acetonitrile; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

1-Bromo-2-bromomethyl-benzene; In tetrahydrofuran; at -78 ℃; for 1h;

Reference yield: 50.0%

acrylonitrile (107-13-1,25014-41-9) + 2-bromobenzoic-acid (88-65-3) → 3-(2-bromo-phenyl)-propionitrile (61698-07-5)

Guidance literature:

With biphenyl; naphthalene-1,4-dicarbonitrile; sodium hydroxide; In water; acetonitrile; at 30 ℃; for 3h; Inert atmosphere; UV-irradiation;

DOI:10.1021/acs.joc.0c00055

upstream raw materials:

cyanomethyl bromide

1-Bromo-2-bromomethyl-benzene

lithioacetonitrile

3-(2-bromo-phenyl)-acrylonitrile

Downstream raw materials:

2-(o-bromobenzyl)-5-methyl-4-hexenenitrile

methyl 3-(4-((2-(2-cyanoethyl)phenyl)ethynyl)-2-fluorophenyl)propanoate

3-(4-((2-(2-cyanoethyl)phenyl)ethynyl)-2-fluorophenyl)propanoic acid

inden-1-one

Refernces

• 1、 Kiyokawa, Kensuke,Nakamura, Shogo,Jou, Keisuke,Iwaida, Kohji,Minakata, Satoshi. "Transition-metal-free Intramolecular C-H amination of sulfamate esters and: N -alkylsulfamides". supporting information. p. 11782 - 11785. Retrieved 2019/10/02.
• 2、 Zhu, Xiaolei,Zhang, Mengmeng,Liu, Jingjing,Ge, Jingming,Yang, Guangfu. "Ametoctradin is a Potent Qo Site Inhibitor of the Mitochondrial Respiration Complex III". . p. 3377 - 3386. Retrieved 2015/04/14.