Phosphinic acid, phenyl-, butyl ester

Base Information

• Chemical Name: Phosphinic acid, phenyl-, butyl ester
• CAS No.: 6172-81-2
• Molecular Formula: C10H15O2P
• Molecular Weight: 198.202
• DSSTox Substance ID: DTXSID20458701
• Wikidata: Q82282183
• Mol file: 6172-81-2.mol

Synonyms:Phosphinic acid, phenyl-, butyl ester;6172-81-2;butoxy-oxo-phenylphosphanium;butyl phenylphosphinate;butyl phenylphosphi-nate;SCHEMBL1726499;DTXSID20458701

Chemical Property of Phosphinic acid, phenyl-, butyl ester

Chemical Property:

• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 197.07314168
• Heavy Atom Count: 13
• Complexity: 153

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCO[P+](=O)C1=CC=CC=C1

Technology Process of Phosphinic acid, phenyl-, butyl ester

There total 16 articles about Phosphinic acid, phenyl-, butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-bromo-butane (109-65-9) + phenylphosphinic acid (1779-48-2) → butyl phenylphosphinate (6172-81-2)

Guidance literature:

With triethylamine; In neat (no solvent); at 80 ℃; for 0.25h; Microwave irradiation;

DOI:10.1039/c4ra03292f

Reference yield: 95.0%

phenylphosphinic acid (1779-48-2) + butan-1-ol (71-36-3) → butyl phenylphosphinate (6172-81-2)

Guidance literature:

phenylphosphinic acid; With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; at 25 ℃; for 0.166667h;

butan-1-ol; In ethyl acetate; at 25 ℃; for 0.5h; Temperature;

DOI:10.1016/j.tet.2014.09.021

Reference yield: 93.0%

tetra(n-butoxy)silane (4766-57-8) + phenylphosphinic acid (1779-48-2) → butyl phenylphosphinate (6172-81-2)

Guidance literature:

In toluene; for 24h; Heating;

DOI:10.1021/ol006434g

upstream raw materials:

dibutyl chlorophosphite

Dichlorophenylphosphine

butan-1-ol

P,P-dichlorophenylphosphine oxide

Downstream raw materials:

3-(butoxy-phenyl-phosphinoyl)-butyric acid ethyl ester

(2-cyano-ethyl)-phenyl-phosphinic acid butyl ester

Phenylchlorophosphonic Acid n-Butyl Ester

butyl phenyl(phenylmethanol) phosphinate

Refernces

• 1、 ábrányi-Balogh, Péter,Harsági, Nikoletta,Keglevich, Gy?rgy,Kiss, Nóra Zsuzsa. "Microwave-assisted esterification of P-acids". . . Retrieved 2021/10/25.
• 2、 Daili, Farah,Ouarti, Abdelhakim,Pinaud, Marine,Kribii, Ibtihal,Sengmany, Stéphane,Le Gall, Erwan,Léonel, Eric. "Nickel-Catalyzed Electrosynthesis of Aryl and Vinyl Phosphinates". supporting information. p. 3452 - 3455. Retrieved 2020/05/25.