4-Amino-2-chlorobenzophenone

Base Information

• Chemical Name: 4-Amino-2-chlorobenzophenone
• CAS No.: 61747-12-4
• Molecular Formula: C13H10ClNO
• Molecular Weight: 231.681
• Hs Code.: 2922399090
• DSSTox Substance ID: DTXSID40471391
• Nikkaji Number: J90.172E
• Wikidata: Q82299891
• Mol file: 61747-12-4.mol

Synonyms:4-amino-2-chlorobenzophenone;61747-12-4;(4-amino-2-chlorophenyl)-phenylmethanone;SCHEMBL5963546;DTXSID40471391;LPWVIVSQYVJOLX-UHFFFAOYSA-N;AKOS013512476

Chemical Property of 4-Amino-2-chlorobenzophenone

Chemical Property:

• PSA: 43.09000
• LogP: 3.73440
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 231.0450916
• Heavy Atom Count: 16
• Complexity: 250

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)C2=C(C=C(C=C2)N)Cl

Technology Process of 4-Amino-2-chlorobenzophenone

There total 7 articles about 4-Amino-2-chlorobenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(2-chloro-4-nitrophenyl)(phenyl)methanone (33663-73-9) → (4-amino-2-chlorophenyl)(phenyl)methanone (61747-12-4)

Guidance literature:

With tin(ll) chloride; In ethanol; at 70 ℃; for 2h;

DOI:10.1021/jm030851s

Reference yield: 90.0%

(4-amino-2-chlorophenyl)phenylacetonitrile (4760-53-6) → (4-amino-2-chlorophenyl)(phenyl)methanone (61747-12-4)

Guidance literature:

With oxygen; potassium carbonate; In water; dimethyl sulfoxide; Ambient temperature;

DOI:10.1021/jo00170a044

Reference yield: 35.0%

3-chloro-aniline (108-42-9) + benzyl alcohol (100-51-6,185532-71-2) → (4-amino-2-chlorophenyl)(phenyl)methanone (61747-12-4)

Guidance literature:

With 3C₁₈H₂₆NO₃⁽¹⁺⁾*HPMo₁₁VO₄₀^(3-); oxygen; In chloroform; dimethyl sulfoxide; at 150 ℃; for 8h; Green chemistry;

DOI:10.1039/c8cy01423j

upstream raw materials:

(2-chloro-4-nitrophenyl)(phenyl)methanone

(4-amino-2-chlorophenyl)phenylacetonitrile

2-chloro-4-nitrobenzoic acid

2-chloro-4-nitrobenzoyl chloride

Downstream raw materials:

{2-chloro-4-[(2-nitrophenyl)amino]phenyl}(phenyl)methanone

4-(4-benzoyl-3-chloroanilino)-6-(1-imidazolyl)quinazoline

6-acetoxy-4-(4-benzoyl-3-chloroanilino)quinazoline hydrochloride salt

(2-Chlor-4-hydroxyphenyl)phenylketon