Propanenitrile, 2-(phenylthio)-3-(trimethylsilyl)-

Base Information

• Chemical Name: Propanenitrile, 2-(phenylthio)-3-(trimethylsilyl)-
• CAS No.: 61829-51-4
• Molecular Formula: C12H17NSSi
• Molecular Weight: 235.425
• Mol file: 61829-51-4.mol

Synonyms:Propanenitrile,2-(phenylthio)-3-(trimethylsilyl);2-(phenylthio)-3-(trimethysilyl)propanenitrile;

Chemical Property of Propanenitrile, 2-(phenylthio)-3-(trimethylsilyl)-

Chemical Property:

• PSA: 49.09000
• LogP: 4.00908

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanenitrile, 2-(phenylthio)-3-(trimethylsilyl)-

There total 2 articles about Propanenitrile, 2-(phenylthio)-3-(trimethylsilyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

(phenylthio)acetonitrile (5219-61-4) + Chloromethyltrimethylsilane (2344-80-1) → (phenylsulfanylmethyl)trimethylsilane (17873-08-4) + 2-(phenylthio)-3-(trimethysilyl)propanenitrile (61829-51-4)

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; Yields of byproduct given; 1.) -78 deg C, 3.5 h, 2.) room temperature, 18 h;

DOI:10.1039/P19810000256

Reference yield:

(phenylthio)acetonitrile (5219-61-4) + Chloromethyltrimethylsilane (2344-80-1) → 2-(phenylthio)-3-(trimethysilyl)propanenitrile (61829-51-4)

Guidance literature:

Multistep reaction; (i) LDA, (ii) /BRN= 906705/;

DOI:10.1039/c39760000751

Reference yield: 91.0%

isopentyl iodide (541-28-6) + 2-(phenylthio)-3-(trimethysilyl)propanenitrile (61829-51-4) → 5-methyl-2-(phenylthio)-2-(trimethylsilylmethyl)hexanenitrile (77412-11-4)

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; for 1.5h; Ambient temperature;

DOI:10.1039/P19810000256

upstream raw materials:

(phenylthio)acetonitrile

Chloromethyltrimethylsilane

Downstream raw materials:

methyl 2-(phenylthio)-3-(trimethylsilyl)propionate

2-(phenylthio)-1-(trimethylsilyl)butan-3-one

5-methyl-2-(phenylthio)-2-(trimethylsilylmethyl)hexanenitrile

2-(phenylthio)-3-(trimethysilyl)propionaldehyde