7,8-Bis(benzyloxy)-1-[(3,4,5-trimethoxyphenyl)methyl]isoquinoline

Base Information

Chemical Name:7,8-Bis(benzyloxy)-1-[(3,4,5-trimethoxyphenyl)methyl]isoquinoline
CAS No.:61831-75-2
Molecular Formula:C33H31NO5
Molecular Weight:521.613
Hs Code.:
DSSTox Substance ID:DTXSID30507532
Wikidata:Q82363803

Synonyms:61831-75-2;7,8-Bis(benzyloxy)-1-(3,4,5-trimethoxybenzyl)isoquinoline;DTXSID30507532;7,8-Bis(benzyloxy)-1-[(3,4,5-trimethoxyphenyl)methyl]isoquinoline

Suppliers and Price of 7,8-Bis(benzyloxy)-1-[(3,4,5-trimethoxyphenyl)methyl]isoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 7,8-Bis(benzyloxy)-1-[(3,4,5-trimethoxyphenyl)methyl]isoquinoline

Chemical Property:

XLogP3:6.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:11
Exact Mass:521.22022309
Heavy Atom Count:39
Complexity:682

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=CC(=C1OC)OC)CC2=NC=CC3=C2C(=C(C=C3)OCC4=CC=CC=C4)OCC5=CC=CC=C5

Technology Process of 7,8-Bis(benzyloxy)-1-[(3,4,5-trimethoxyphenyl)methyl]isoquinoline

There total 8 articles about 7,8-Bis(benzyloxy)-1-[(3,4,5-trimethoxyphenyl)methyl]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 78283-45-1
2-benzoyl-7,8-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-1,2-dihydroisoquinoline-1-carbonitrile

: 61831-75-2
7,8-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)isoquinoline

Guidance literature:: With sodium hydroxide; In ethanol; water; for 2h; Heating;
DOI:10.1248/cpb.29.744

Reference yield:

: 5779-91-9
2,3-bis(benzyloxy)benzaldehyde

: 61831-75-2
7,8-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)isoquinoline

Guidance literature:: Multi-step reaction with 8 steps

1: 62 percent / 0.17 h / 85 - 90 °C

2: 67 percent / NaBH₄ / ethanol / 2 h / Heating

3: pyridine / 12 h / Ambient temperature

4: 65 percent / conc. HCl / dioxane / 2 h / Heating

5: 97 percent / t-BuOK / 2-methyl-propan-2-ol / 2 h / 90 °C

6: 70 percent / CH₂Cl₂; H₂O / ice cooling, 1.5 h, then Rt, 18 h

7: 57 percent / 1.) NaH / dimethylformamide / 0.5 h / -8 - 22 °C

8: 85 percent / NaOH / ethanol; H₂O / 2 h / Heating

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; potassium tert-butylate; sodium hydride; In 1,4-dioxane; pyridine; ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1248/cpb.29.744

Reference yield:

: 61831-72-9
7,8-dibenzyloxyisoquinoline

: 61831-75-2
7,8-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)isoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / CH₂Cl₂; H₂O / ice cooling, 1.5 h, then Rt, 18 h

2: 57 percent / 1.) NaH / dimethylformamide / 0.5 h / -8 - 22 °C

3: 85 percent / NaOH / ethanol; H₂O / 2 h / Heating

With sodium hydroxide; sodium hydride; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.29.744