2-benzoyl-7,8-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-1,2-dihydroisoquinoline-1-carbonitrile

Base Information

Chemical Name:2-benzoyl-7,8-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-1,2-dihydroisoquinoline-1-carbonitrile
CAS No.:78283-45-1
Molecular Formula:C₄₁H₃₆N₂O₆
Molecular Weight:652.747
Hs Code.:

Synonyms:2-benzoyl-7,8-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-1,2-dihydroisoquinoline-1-carbonitrile

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Chemical Property of 2-benzoyl-7,8-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-1,2-dihydroisoquinoline-1-carbonitrile

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Technology Process of 2-benzoyl-7,8-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-1,2-dihydroisoquinoline-1-carbonitrile

There total 8 articles about 2-benzoyl-7,8-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-1,2-dihydroisoquinoline-1-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 61831-73-0
2-Benzoyl-7,8-bis-benzyloxy-1,2-dihydro-isoquinoline-1-carbonitrile

: 3840-30-0
5-(chloromethyl)-1,2,3-trimethoxybenzene

: 78283-45-1
2-benzoyl-7,8-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-1,2-dihydroisoquinoline-1-carbonitrile

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at -8 - 22 ℃; for 0.5h;
DOI:10.1248/cpb.29.744

Reference yield:

: 5779-91-9
2,3-bis(benzyloxy)benzaldehyde

: 78283-45-1
2-benzoyl-7,8-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-1,2-dihydroisoquinoline-1-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: 62 percent / 0.17 h / 85 - 90 °C

2: 67 percent / NaBH₄ / ethanol / 2 h / Heating

3: pyridine / 12 h / Ambient temperature

4: 65 percent / conc. HCl / dioxane / 2 h / Heating

5: 97 percent / t-BuOK / 2-methyl-propan-2-ol / 2 h / 90 °C

6: 70 percent / CH₂Cl₂; H₂O / ice cooling, 1.5 h, then Rt, 18 h

7: 57 percent / 1.) NaH / dimethylformamide / 0.5 h / -8 - 22 °C

With hydrogenchloride; sodium tetrahydroborate; potassium tert-butylate; sodium hydride; In 1,4-dioxane; pyridine; ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1248/cpb.29.744

Reference yield:

: 98-88-4
benzoyl chloride

: 78283-45-1
2-benzoyl-7,8-dibenzyloxy-1-(3,4,5-trimethoxybenzyl)-1,2-dihydroisoquinoline-1-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / CH₂Cl₂; H₂O / ice cooling, 1.5 h, then Rt, 18 h

2: 57 percent / 1.) NaH / dimethylformamide / 0.5 h / -8 - 22 °C

With sodium hydride; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.29.744