2-(Pyridin-2-yloxy)ethanamine

Base Information

• Chemical Name: 2-(Pyridin-2-yloxy)ethanamine
• CAS No.: 29450-07-5
• Molecular Formula: C7H10 N2 O
• Molecular Weight: 138.169
• Hs Code.: 2933399090
• European Community (EC) Number: 249-634-1
• NSC Number: 91884
• UNII: HK4L7KQC0J
• DSSTox Substance ID: DTXSID30183658
• Nikkaji Number: J250.844C
• Wikidata: Q83054479
• ChEMBL ID: CHEMBL1741877
• Mol file: 29450-07-5.mol

Synonyms:2-(pyridin-2-yloxy)ethanamine;29450-07-5;2-(2-PYRIDYLOXY)ETHANAMINE;2-(2-Aminoethoxy)pyridine;2-pyridin-2-yloxyethanamine;Ethanamine, 2-(2-pyridinyloxy)-;2-(PYRIDIN-2-YLOXY)-ETHYLAMINE;NSC91884;NSC-91884;HK4L7KQC0J;2-(2-pyridinyloxy)ethanamine;EINECS 249-634-1;MFCD00090835;aminoethoxypyridine;2-(pyridin-2-yloxy)ethan-1-amine;UNII-HK4L7KQC0J;2-(2-pyridyloxy)ethylamine;NCIStruc1_001752;NCIStruc2_000056;2-(2-pyridinyloxy) ethylamine;2-(pyridin-2-yloxy)ethylamine;SCHEMBL1178754;CHEMBL1741877;DTXSID30183658;[2-(pyridin-2-yloxy)ethyl]amine;2-( Pyridin-2-yloxy)-ethylamine;NCI91884;CCG-37763;NCGC00013960;NSC 91884;AKOS011633460;AB03271;CS-W002359;NCGC00013960-02;NCGC00097069-01;AC-29360;NCI60_042032;SY020759;AM20120568;EN300-634603;A876457;F2147-1481

Chemical Property of 2-(Pyridin-2-yloxy)ethanamine

Chemical Property:

• Vapor Pressure: 0.0552mmHg at 25°C
• Melting Point: 216-222 °C
• Boiling Point: 233.7°Cat760mmHg
• PKA: 8.22±0.10(Predicted)
• Flash Point: 95.1°C
• PSA: 48.14000
• Density: 1.089g/cm³
• LogP: 1.11940
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 138.079312947
• Heavy Atom Count: 10
• Complexity: 87.7

Purity/Quality:

97% ^*data from raw suppliers

2-(Pyridin-2-yloxy)ethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)OCCN

Technology Process of 2-(Pyridin-2-yloxy)ethanamine

There total 2 articles about 2-(Pyridin-2-yloxy)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-chloropyridine (109-09-1) + ethanolamine (141-43-5) → 2-(pyridin-2-yloxy)ethanamine (29450-07-5)

Guidance literature:

With sodium hydride; In 1,4-dioxane; for 18h; Heating;

DOI:10.1016/S0040-4020(01)85096-1

Reference yield:

→ 2-(pyridin-2-yloxy)ethanamine (29450-07-5)

Guidance literature:

entspr. Halopyridin, entspr. Metallsalz d. Alkohols;

Reference yield: 80.0%

2-(pyridin-2-yloxy)ethanamine (29450-07-5) + C15H12FN5O5 → C22H21FN6O4

Guidance literature:

With triethylamine; In tetrahydrofuran; at 40 ℃; for 5h;

upstream raw materials:

2-chloropyridine

ethanolamine

Downstream raw materials:

N-(2-(pyridin-2-yloxy)-ethyl)-thioacetamide

5-(4-butylphenoxy)-2,2-dimethyl-N-[2-(2-pyridinyloxy)ethyl]pentanamide

3-oxo-2-(2-(pyridin-2-yloxy)ethyl)-N-(4-(trifluoromethoxy)benzyl)isoindoline-1-carboxamide