1,3-Diphenyl-3-hydroxy-2-methyl-1-propanone

Base Information

• Chemical Name: 1,3-Diphenyl-3-hydroxy-2-methyl-1-propanone
• CAS No.: 61878-73-7
• Molecular Formula: C16H16O2
• Molecular Weight: 240.302
• DSSTox Substance ID: DTXSID80436681
• Nikkaji Number: J271.346B
• Mol file: 61878-73-7.mol

Synonyms:1,3-diphenyl-3-hydroxy-2-methyl-1-propanone;3-hydroxy-2-methyl-1,3-diphenylpropan-1-one;61878-73-7;SCHEMBL5595457;DTXSID80436681;YJPANUWAQYSUPC-UHFFFAOYSA-N;1-Phenyl-2-(alpha-hydroxybenzyl)-1-propanone;3-hydroxy-2-methyl-1,3-diphenyl-1-propanone

Chemical Property of 1,3-Diphenyl-3-hydroxy-2-methyl-1-propanone

Chemical Property:

• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 240.115029749
• Heavy Atom Count: 18
• Complexity: 262

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C(C1=CC=CC=C1)O)C(=O)C2=CC=CC=C2

Technology Process of 1,3-Diphenyl-3-hydroxy-2-methyl-1-propanone

There total 103 articles about 1,3-Diphenyl-3-hydroxy-2-methyl-1-propanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-phenyl-1-trimethylsiloxypropene (37471-46-8) + benzaldehyde (100-52-7) → 3-hydroxy-2-methyl-1,3-diphenyl-propan-1-one (61878-73-7)

Guidance literature:

tin(IV) chloride; zinc(II) chloride; In dichloromethane; at -78 ℃; for 2h;

DOI:10.1246/bcsj.61.4037

Reference yield: 98.0%

trimethyl[(Z)-(1-phenyl-1-propenyl)oxy]silane (66323-99-7) + benzaldehyde (100-52-7) → 3-hydroxy-2-methyl-1,3-diphenyl-propan-1-one (61878-73-7)

Guidance literature:

hafnium tetrachloride; In acetonitrile; at 20 ℃; for 0.25h;

DOI:10.1002/chem.200700010

Reference yield: 97.0%

propiophenone lithium enolate (57204-88-3) + benzaldehyde (100-52-7) → 3-hydroxy-2-methyl-1,3-diphenyl-propan-1-one (61878-73-7)

Guidance literature:

With benzylidene phenylamine; In tetrahydrofuran; at -78 ℃;

DOI:10.1021/jo962010h

upstream raw materials:

1-phenyl-1-trimethylsiloxypropene

benzaldehyde dimethyl acetal

benzaldehyde

2-iodo-1-phenylpropan-1-one

Downstream raw materials:

1,3-diphenyl-2-methylpropane-1,3-dione

anti-3-methoxy-2-methyl-1,3-diphenyl-1-propanone