57204-88-3

Upstream product

• 93-55-0 1-phenyl-propan-1-one 
• 137604-19-4 Lithium; 1-phenyl-prop-2-en-1-olate 
• 591-51-5 phenyllithium 

Downstream Products

• 93617-69-7 2-(1-Methyl-2-oxo-2-phenyl-ethyl)-2H-pyridine-1-carboxylic acid phenyl ester 
• 93617-68-6 4-(1-Methyl-2-oxo-2-phenyl-ethyl)-4H-pyridine-1-carboxylic acid phenyl ester 
• 52776-41-7 2,3-dimethyl-1-phenyl-2-butene-1-one 
• 34733-55-6 2,3-dimethyl-1,4-diphenyl-butane-1,4-dione 
• 78706-73-7 2,3-dimethyl-3-nitro-1-phenyl-1-butanone 
• 14897-67-7 2-nitropropiophenone 
• 14195-15-4 α-(p-methylbenzenesulfonyl)propiophenone 
• 97467-22-6 [(E)-1-(2,2-Dimethyl-hex-5-enyloxy)-propenyl]-benzene 
• 71908-02-6 (2SR,3RS)-3-hydroxy-2-methyl-1,3-diphenylpropan-1-one 
• 71908-03-7 (2SR,3RS)-2-methyl-1,3-diphenyl-3-hydroxypropan-1-one 
• 73739-31-8 (3SR,2SR)-1-phenyl-2-methyl-3-hydroxy-pentan-1-one 
• 73739-31-8 (3SR,2RS)-1-phenyl-2-methyl-3-hydroxy-pentan-1-one 
• 61878-73-7 3-hydroxy-2-methyl-1,3-diphenyl-propan-1-one 
• 1197189-53-9 (Z)-dimethyl(2-methylallyl)(1-phenylprop-1-enyloxy)silane 

Relevant academic research and scientific papers

Highly functionalized and potent antiviral cyclopentane derivatives formed by a tandem process consisting of organometallic, transition-metal-catalyzed, and radical reaction steps

A simple modular tandem approach to multiply substituted cyclopentane derivatives is reported, which succeeds by joining organometallic addition, conjugate addition, radical cyclization, and oxygenation steps. The key steps enabling this tandem process are the thus far rarely used isomerization of allylic alkoxides to enolates and single-electron transfer to merge the organometallic step with the radical and oxygenation chemistry. This controlled lineup of multiple electronically contrasting reactive intermediates provides versatile access to highly functionalized cyclopentane derivatives from very simple and readily available commodity precursors. The antiviral activity of the synthesized compounds was screened and a number of compounds showed potent activity against hepatitisC and dengue viruses.

EVIDENCE FOR SINGLE ELECTRON TRANSFER IN THE REACTION OF A LITHIUM ENOLATE WITH A PRIMARY ALKYL IODIDE

Evidence for a radical process in the reaction of the lithium enolate of propiophenone with a primary alkyl iodide was obtained by the observation of cyclization of an appropriate radical probe, by the trapping of the radical intermediate and by the comparison of the relative rates of reactions of the probe alkyl iodide with the corresponding bromide and tosylate.