METHYL 2-BROMOMETHYL-6-NITRO-BENZOATE

Base Information

• Chemical Name: METHYL 2-BROMOMETHYL-6-NITRO-BENZOATE
• CAS No.: 61940-21-4
• Molecular Formula: C9H8BrNO4
• Molecular Weight: 274.071
• Hs Code.: 2916399090
• Mol file: 61940-21-4.mol

Synonyms:methyl 2-(bromomethyl)-6-nitrobenzoate;

Chemical Property of METHYL 2-BROMOMETHYL-6-NITRO-BENZOATE

Chemical Property:

• Melting Point: 84-86°C
• PSA: 72.12000
• LogP: 2.79950
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Bromomethyl-6-nitrobenzoicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Bromomethyl-6-nitrobenzoic Acid Methyl Ester is a potential cyclooxygenase inhibitor derived from thalidomide (T338850), an immunomodulatory agent used primarily in combination with dexamethasone to treat multiple myeloma.

Technology Process of METHYL 2-BROMOMETHYL-6-NITRO-BENZOATE

There total 4 articles about METHYL 2-BROMOMETHYL-6-NITRO-BENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl 2-methyl-6-nitrobenzoate (61940-22-5) → methyl 2-(bromomethyl)-6-nitrobenzoate (61940-21-4)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; at 80 ℃; for 16h;

Reference yield: 71.0%

methyl 2-methyl-6-nitrobenzoate (61940-22-5) + dibenzoyl peroxide (94-36-0) → methyl 2-(bromomethyl)-6-nitrobenzoate (61940-21-4)

Guidance literature:

With N-Bromosuccinimide; In 1,2-dichloro-ethane; for 8h; Reflux;

Reference yield: 62.0%

→ methyl 2-(bromomethyl)-6-nitrobenzoate (61940-21-4)

Guidance literature:

upstream raw materials:

methyl 2-methyl-6-nitrobenzoate

2-methyl-6-nitrobenzoic acid

dibenzoyl peroxide

Downstream raw materials:

methyl 2-(methoxymethyl)-6-nitro-benzoate

7-amino-2-(cyclohexylmethyl)isoindolin-1-one

N-[2-(α-methoxymethyl)-6-nitrobenzyl]-glycine ethyl ester

2-(α-methoxymethyl)-6-nitrobenzoic acid

Refernces

• 1、 Laleu, Beno?t,Akao, Yuichiro,Ochida, Atsuko,Duffy, Sandra,Lucantoni, Leonardo,Shackleford, David M.,Chen, Gong,Katneni, Kasiram,Chiu, Francis C. K.,White, Karen L.,Chen, Xue,Sturm, Angelika,Dechering, Koen J.,Crespo, Benigno,Sanz, Laura M.,Wang, Binglin,Wittlin, Sergio,Charman, Susan A.,Avery, Vicky M.,Cho, Nobuo,Kamaura, Masahiro. "Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials". . p. 12582 - 12602. Retrieved 2021/09/13.
• 2、 -. "EGFR PROTEOLYSIS TARGETING CHIMERIC MOLECULES AND ASSOCIATED METHODS OF USE". Paragraph 001004; 001005. . Retrieved 2018/07/29.