METHYL-2METHYL-6-NITRO-BENZOATE

Base Information

• Chemical Name: METHYL-2METHYL-6-NITRO-BENZOATE
• CAS No.: 61940-22-5
• Molecular Formula: C9H9NO4
• Molecular Weight: 195.175
• Hs Code.: 2916399090
• Mol file: 61940-22-5.mol

Synonyms:METHYL-2METHYL-6-NITRO-BENZOATE

Chemical Property of METHYL-2METHYL-6-NITRO-BENZOATE

Chemical Property:

• Vapor Pressure: 0.00317mmHg at 25°C
• Refractive Index: 1.548
• Boiling Point: 283.4°C at 760 mmHg
• Flash Point: 126.4°C
• PSA: 72.12000
• Density: 1.255g/cm³
• LogP: 2.21300
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DCM, Methanol

Purity/Quality:

98%Min ^*data from raw suppliers

2-Methyl-6-nitrobenzoicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Methyl-6-nitrobenzoic Acid Methyl Ester is an ester derivative of 2-Methyl-nitrobenzoic Acid (M325545), an derivative of Anthranilic Acid (A679220).

Technology Process of METHYL-2METHYL-6-NITRO-BENZOATE

There total 10 articles about METHYL-2METHYL-6-NITRO-BENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-methyl-6-nitrobenzoic acid (13506-76-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → methyl 2-methyl-6-nitrobenzoate (61940-22-5)

Guidance literature:

With oxalyl dichloride; In dichloromethane; for 2h; Reflux;

Reference yield: 98.0%

2-methyl-6-nitrobenzoic acid (13506-76-8) + methyl iodide (74-88-4) → methyl 2-methyl-6-nitrobenzoate (61940-22-5)

Guidance literature:

With potassium carbonate; In acetone; Heating;

DOI:10.1039/b512877c

Reference yield: 91.0%

Trimethyl orthoacetate (1445-45-0) + 2-methyl-6-nitrobenzoic acid (13506-76-8) → methyl 2-methyl-6-nitrobenzoate (61940-22-5)

Guidance literature:

at 20 - 100 ℃; for 2h; Inert atmosphere;

upstream raw materials:

methanol

2-methyl-6-nitrobenzoyl chloride

2-methyl-6-nitrobenzoic acid

methyl iodide

Downstream raw materials:

2-amino-6-methylbenzoic acid methyl ester

7-amino-2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]isoindolin-1-one

(1S)-7-nitro-2-[1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)-ethyl]isoindolin-1-one

methyl 6-amino-3-bromo-2-methylbenzoate

Refernces

• 1、 Laleu, Beno?t,Akao, Yuichiro,Ochida, Atsuko,Duffy, Sandra,Lucantoni, Leonardo,Shackleford, David M.,Chen, Gong,Katneni, Kasiram,Chiu, Francis C. K.,White, Karen L.,Chen, Xue,Sturm, Angelika,Dechering, Koen J.,Crespo, Benigno,Sanz, Laura M.,Wang, Binglin,Wittlin, Sergio,Charman, Susan A.,Avery, Vicky M.,Cho, Nobuo,Kamaura, Masahiro. "Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials". . p. 12582 - 12602. Retrieved 2021/09/13.
• 2、 Chen, Qiong,Hao, Ge-Fei,He, Bo,Lin, Hong-Yan,Wu, Feng-Xu,Wu, Lei,Yang, Guang-Fu,Yang, Wen-Chao,Yu, Liang-Kun. "Discovery of Novel Pyrazole-Quinazoline-2,4-dione Hybrids as 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors". . p. 5059 - 5067. Retrieved 2020/05/20.