Ctopa

Base Information

• Chemical Name: Ctopa
• CAS No.: 103429-31-8
• Molecular Formula: C50H67 N11 O11 S2
• Molecular Weight: 1062.28
• Mol file: 103429-31-8.mol

Synonyms:CTOP;CTOP-NH2;CTOPA;Cys(2)-Tyr(3)-Orn(5)-Pen(7)-amide;Phe-cycl(Cys-Tyr-Trp-Orn-Thr-Pen)Thr-NH2;phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide

Chemical Property of Ctopa

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 1491.2°Cat760mmHg
• PKA: 9.90±0.15(Predicted)
• Flash Point: 855.7°C
• PSA: 425.91000
• Density: 1.42g/cm³
• LogP: 3.30840
• Storage Temp.: −20°C
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 14
• Hydrogen Bond Acceptor Count: 15
• Rotatable Bond Count: 16
• Exact Mass: 1061.44629434
• Heavy Atom Count: 74
• Complexity: 1930

Purity/Quality:

98%,99%, ^*data from raw suppliers

Naltriben ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C1C(=O)NC(C(SSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN)CC2=CNC3=CC=CC=C32)CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC=CC=C5)N)(C)C)C(=O)NC(C(C)O)C(=O)N)O
• Uses: CTOP is a μ-opioid receptor antagonist which has been shown to regulate behaviour and expression in rats. An endogenous opioid peptide which may also be used in the treatment of pain through improved morphine tolerance via blocking of mTOR. CTOP has been used:to study the anxiogenic effects induced by CTOP in mice and rat.to study the effect of μ-opioid antagonist, CTOP on the bovine milk-derived LF (BLF)-induced analgesia.to determine whether μ-opioid receptors act cooperatively with 5-hydroxytryptamine (5-HT1A) receptors to regulate the behaviors generated in the elevated T-maze (ETM).

Technology Process of Ctopa

There total 5 articles about Ctopa which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 hydrochloride → D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (103429-31-8)

Guidance literature:

With ammonium acetate; potassium hexacyanoferrate(III); for 1h; Yield given; Ambient temperature;

DOI:10.1021/jm00161a037

Reference yield:

N-Boc-O-benzyl-L-threonine (15260-10-3) → D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (103429-31-8)

Guidance literature:

Multi-step reaction with 2 steps

2: aq. AcONH₄, 0.01 M K₃Fe(CN)6 / 1 h / Ambient temperature

With ammonium acetate; potassium hexacyanoferrate(III);

DOI:10.1021/jm00161a037

Reference yield:

Boc-Orn(Z)-OH (2480-93-5) → D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (103429-31-8)

Guidance literature:

Multi-step reaction with 2 steps

2: aq. AcONH₄, 0.01 M K₃Fe(CN)6 / 1 h / Ambient temperature

With ammonium acetate; potassium hexacyanoferrate(III);

DOI:10.1021/jm00161a037

upstream raw materials:

N-Boc-O-benzyl-L-threonine

Boc-Orn(Z)-OH

Boc-D-Trp-OH

N^α-Boc-L-Pen(S-4'-methylbenzyl)

Refernces