5-Aminopyridine-3-sulfonamide

Base Information

• Chemical Name: 5-Aminopyridine-3-sulfonamide
• CAS No.: 62009-21-6
• Molecular Formula: C5H7N3O2S
• Molecular Weight: 173.19300
• Hs Code.: 2935009090
• European Community (EC) Number: 863-970-1
• DSSTox Substance ID: DTXSID10506801
• Wikidata: Q82362735
• Mol file: 62009-21-6.mol

Synonyms:5-Aminopyridine-3-sulfonamide;62009-21-6;5-AMINO-3-PYRIDINESULFONAMIDE;3-Pyridinesulfonamide, 5-amino-;5-AMINO-3-PYRIDINESULFONAMIDE,95+%;5-azanylpyridine-3-sulfonamide;SCHEMBL3662570;DTXSID10506801;LICDCKVYZROEQG-UHFFFAOYSA-N;3-Pyridinesulfonamide,5-amino-(9CI);AKOS006228741;SB54965;CS-0139493;FT-0713937;A21646;EN300-216639;A838548;J-516722;Z1198315197

Chemical Property of 5-Aminopyridine-3-sulfonamide

Chemical Property:

• PSA: 107.45000
• LogP: 1.67350
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: -1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 173.02589765
• Heavy Atom Count: 11
• Complexity: 220

Purity/Quality:

98%Min ^*data from raw suppliers

5-aminopyridine-3-sulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=C(C=NC=C1S(=O)(=O)N)N

Technology Process of 5-Aminopyridine-3-sulfonamide

There total 4 articles about 5-Aminopyridine-3-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.5%

5-bromopyridine-3-sulfonamide (62009-33-0) → 5-aminopyridine-3-sulfonamide (62009-21-6)

Guidance literature:

With ammonium hydroxide; copper(II) sulfate; at 170 ℃; for 5h;

DOI:10.1021/jm00186a017

Reference yield:

5-bromopyridine-3-sulfonamide (62009-33-0) + copper(II) sulfate (7758-99-8) → 5-aminopyridine-3-sulfonamide (62009-21-6)

Guidance literature:

With ammonium hydroxide; sodium sulfide;

Reference yield:

5-bromopyridine-3-sulphonyl chloride (65001-21-0) → 5-aminopyridine-3-sulfonamide (62009-21-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 20percent NH₄OH / 1 h

2: 61.5 percent / CuSO₅*5H₂O, conc. NH₄OH / 5 h / 170 °C

With ammonium hydroxide; copper(II) sulfate;

DOI:10.1021/jm00186a017

upstream raw materials:

5-bromopyridine-3-sulfonamide

5-bromopyridine-3-sulphonyl chloride

copper(II) sulfate

Downstream raw materials:

5-nitropyridine-3-sulfonamide

N-(5-sulfamoylpyridin-3-yl)-4-(trifluoromethyl)-2-(6-(trifluoromethyl)pyridin-3-yloxy)benzamide

Refernces

• 1、 -. "Pyridine sulfonamides and their use as anticoccidial agents". . . Retrieved 2008/06/13.