Technology Process of Piperidine, 3-(3,4-dimethoxyphenyl)-1-propyl-
There total 14 articles about Piperidine, 3-(3,4-dimethoxyphenyl)-1-propyl- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: tetrahydrofuran / 0.5 h / 60 °C
2: TsOH / benzene / 4 h / Heating
3: 63 percent / NaH / tetrahydrofuran / 0.5 h / Heating
4: NaBH4 / methanol; tetrahydrofuran / 2 h / 4 - 7 °C
5: BF3*Et2O; MgSO4 / CH2Cl2 / 5 h / 20 °C
6: H2 / Pd(OH)2/C / acetic acid / 3 h / 20 °C
7: Na/Hg; Na3PO4 / methanol / 2 h / 20 °C
8: 92 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating
With
sodium tetrahydroborate; sodium amalgam; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; hydrogen; sodium hydride; magnesium sulfate; toluene-4-sulfonic acid; sodium phosphate;
palladium dihydroxide;
In
tetrahydrofuran; methanol; dichloromethane; acetic acid; benzene;
DOI:10.1016/S0040-4020(02)00282-X
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
for 3h;
Heating;
DOI:10.1021/jm00144a021