1-[3-(3,4-Dimethoxyphenyl)piperidin-1-yl]propan-1-one

Base Information

Chemical Name:1-[3-(3,4-Dimethoxyphenyl)piperidin-1-yl]propan-1-one
CAS No.:62033-62-9
Molecular Formula:C16H23NO3
Molecular Weight:277.364
Hs Code.:
DSSTox Substance ID:DTXSID60513449

Synonyms:62033-62-9;1-[3-(3,4-Dimethoxyphenyl)piperidin-1-yl]propan-1-one;SCHEMBL11624456;DTXSID60513449;KFOKBYKTEYEHJB-UHFFFAOYSA-N;N-propionyl-3-(3',4'-dimethoxyphenyl)-piperidine

Suppliers and Price of 1-[3-(3,4-Dimethoxyphenyl)piperidin-1-yl]propan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[3-(3,4-Dimethoxyphenyl)piperidin-1-yl]propan-1-one

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:277.16779360
Heavy Atom Count:20
Complexity:321

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC(=O)N1CCCC(C1)C2=CC(=C(C=C2)OC)OC

Technology Process of 1-[3-(3,4-Dimethoxyphenyl)piperidin-1-yl]propan-1-one

There total 3 articles about 1-[3-(3,4-Dimethoxyphenyl)piperidin-1-yl]propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 626-55-1,163928-56-1
3-Bromopyridine

: 62033-62-9
N-propionyl-3-(3',4'-dimethoxyphenyl)-piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: dichlorobis(triphenylphosphine)nickel(II) / tetrahydrofuran / 24 h / Ambient temperature

2: H₂, conc. HCl / PtO₂ / methanol / 2585.7 Torr

3: Et₃N / toluene / 0.5 h / Ambient temperature

With hydrogenchloride; bis(triphenylphosphine)nickel(II) chloride; hydrogen; triethylamine; platinum(IV) oxide; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm00144a021

Reference yield:

: 89980-69-8
3,4-dimethoxyphenylmagnesium bromide

: 62033-62-9
N-propionyl-3-(3',4'-dimethoxyphenyl)-piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: dichlorobis(triphenylphosphine)nickel(II) / tetrahydrofuran / 24 h / Ambient temperature

2: H₂, conc. HCl / PtO₂ / methanol / 2585.7 Torr

3: Et₃N / toluene / 0.5 h / Ambient temperature

With hydrogenchloride; bis(triphenylphosphine)nickel(II) chloride; hydrogen; triethylamine; platinum(IV) oxide; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm00144a021

Reference yield:

: 79445-45-7
3-(3,4-Dimethoxyphenyl)pyridine

: 62033-62-9
N-propionyl-3-(3',4'-dimethoxyphenyl)-piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: H₂, conc. HCl / PtO₂ / methanol / 2585.7 Torr

2: Et₃N / toluene / 0.5 h / Ambient temperature

With hydrogenchloride; hydrogen; triethylamine; platinum(IV) oxide; In methanol; toluene;
DOI:10.1021/jm00144a021