3,5-Bis(chloromethyl)-1,2,4-oxadiazole

Base Information

• Chemical Name: 3,5-Bis(chloromethyl)-1,2,4-oxadiazole
• CAS No.: 1194-01-0
• Molecular Formula: C4H4 Cl2 N2 O
• Molecular Weight: 166.9934
• DSSTox Substance ID: DTXSID50152442
• Wikidata: Q83019073
• Mol file: 1194-01-0.mol

Synonyms:3,5-Bis(chloromethyl)-1,2,4-oxadiazole;1194-01-0;1,2,4-Oxadiazole, 3,5-bis(chloromethyl)-;3,5-di(chloromethyl)-1,2,4-oxadiazole;C4-H4-Cl2-N2-O;SCHEMBL11165171;DTXSID50152442;DGVAPROAWBSWQI-UHFFFAOYSA-N;MFCD01809085;AKOS006383652;3,5-di-(chloromethyl)-1,2,4-oxadiazole;BIS(CHLOROMETHYL)-1,2,4-OXADIAZOLE

Chemical Property of 3,5-Bis(chloromethyl)-1,2,4-oxadiazole

Chemical Property:

• Vapor Pressure: 0.031mmHg at 25°C
• Boiling Point: 252.3°Cat760mmHg
• Flash Point: 106.4°C
• Density: 1.463g/cm³
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 165.9700681
• Heavy Atom Count: 9
• Complexity: 92.6

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C1=NOC(=N1)CCl)Cl

Technology Process of 3,5-Bis(chloromethyl)-1,2,4-oxadiazole

There total 1 articles about 3,5-Bis(chloromethyl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

Chloroacetamidoxime-15N-NH2 + chloroacetonitrile (107-14-2) → 3,5-di-(chloromethyl)-1,2,4-oxadiazole (1194-01-0)

Guidance literature:

With hydrogenchloride; zinc(II) chloride; In acetic acid butyl ester; for 0.333333h; Heating;

DOI:10.1016/S0040-4020(01)90529-0

Reference yield:

3,5-di-(chloromethyl)-1,2,4-oxadiazole (1194-01-0) + para-bromobenzenethiol (106-53-6) → 3,5-di-(4-bromophenylthiomethyl)-1,2,4-oxadiazole

Guidance literature:

With sodium; In ethanol;

Reference yield:

3,5-di-(chloromethyl)-1,2,4-oxadiazole (1194-01-0) + 2-amino-benzenethiol (137-07-5) → 3,5-Di-(2-aminophenylthiomethyl)-1,2,4-oxadiazole

Guidance literature:

In ethanol; sodium;

upstream raw materials:

chloroacetonitrile