1H-Thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-1-(trifluoroacetyl)-, 4-nitrophenyl ester

Base Information

• Chemical Name: 1H-Thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-1-(trifluoroacetyl)-, 4-nitrophenyl ester
• CAS No.: 62062-42-4
• Molecular Formula: C18H18F3N3O6S
• Molecular Weight: 461.419
• Mol file: 62062-42-4.mol

Synonyms:

Chemical Property of 1H-Thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-1-(trifluoroacetyl)-, 4-nitrophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-1-(trifluoroacetyl)-, 4-nitrophenyl ester

There total 1 articles about 1H-Thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-1-(trifluoroacetyl)-, 4-nitrophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-nitro-4-trifluoroacetoxy-benzene (658-78-6) + biotin (58-85-5,22879-79-4) → 5-((3aS)-2-oxo-1-trifluoroacetyl-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl)-pentanoic acid 4-nitro-phenyl ester (62062-42-4)

Guidance literature:

With pyridine; 4-nitro-phenol; at 50 ℃;

DOI:10.1021/ja00443a040

Reference yield:

5-((3aS)-2-oxo-1-trifluoroacetyl-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl)-pentanoic acid 4-nitro-phenyl ester (62062-42-4) → Boc-Lys(biotinyl)-OH (62062-43-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. EtOH / Heating

2: Py, aq. NaOH

With pyridine; sodium hydroxide; ethanol;

DOI:10.1021/ja00443a040

Reference yield:

5-((3aS)-2-oxo-1-trifluoroacetyl-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl)-pentanoic acid 4-nitro-phenyl ester (62062-42-4) → biocytin (576-19-2)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. EtOH / Heating

2: Py, aq. NaOH

3: aq. CF₃CO₂H, anisole

With pyridine; sodium hydroxide; ethanol; methoxybenzene; trifluoroacetic acid;

DOI:10.1021/ja00443a040

upstream raw materials:

1-nitro-4-trifluoroacetoxy-benzene

biotin

Downstream raw materials:

D-(+)-biotin 2-nitrophenyl ester

Boc-Lys(biotinyl)-OH

biocytin